1-Formyl-beta-carboline

1-Formyl-beta-carboline

• CAS Number: 20127-63-3
• UNSPSC Description: 1-Formyl-beta-carboline is an alkaloid with inhibitory activity against Newcastle disease virus (NDV). 1-Formyl-beta-carboline can effectively inhibit different genotypes of NDV with IC50 values within 10 μM, and its inhibition rate is more than 90% at a concentration of 20 μM. 1-Formyl-beta-carboline mainly exerts its effects by inhibiting the adsorption and entry processes in the NDV life cycle. 1-Formyl-beta-carboline has been identified as a novel HN inhibitor that can directly interact with the NDV HN protein and affect the adsorption of NDV. 1-Formyl-beta-carboline also inhibits the entry of NDV by inhibiting the PI3K/Akt signaling pathway rather than the ERK pathway[1].
• Target Antigen: Akt
• Type: Natural Products
• Related Pathways: PI3K/Akt/mTOR
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/1-formyl-beta-carboline.html
• Purity: 99.70
• Smiles: C1=CC=C2C(=C1)C3=C(C(=NC=C3)C=O)N2
• Molecular Weight: 196.209
• References & Citations: [1]1-Formyl- β-carboline Derivatives Block Newcastle Disease Virus Proliferation through Suppressing Viral Adsorption and Entry Processes
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported