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Viquidacin

CAT: 0804-HY-14780Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-14780Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Viquidacin (NXL 101) is an antibiotic with inhibitory activity against topoisomerase IV and DNA gyrase. Viquidacin exhibits antibacterial activity against gram positive bacterial by inhibiting the supercoiling, decatenation and relaxation in strains Staphylococcus aureus and Escherichia coli in micromolar levels. Viquidacin inhibits S. aureus wildtype and mutants with MIC of 2-128 mg/L[1].
CAS Number
904302-98-3
Product Name Alternative
NXL 101
UNSPSC
12352005
Target
Antibiotic; Bacterial; DNA/RNA Synthesis; Topoisomerase
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/viquidacin.html
Smiles
[H][C@@](C1)(C(O)=O)[C@@](CC[C@]([H])(O)C2=C(F)C=NC3=C2C=C(OC)C=C3)([H])CCN1CCSC4=CC=CS4
Molecular Formula
C25H29FN2O4S2
Molecular Weight
504.64
References & Citations
[1]Black MT, et al., Mechanism of action of the antibiotic NXL101, a novel nonfluoroquinolone inhibitor of bacterial type II topoisomerases. Antimicrob Agents Chemother. 2008 Sep;52 (9) :3339-49.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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