2'-Deoxyuridine (Standard)

2'-Deoxyuridine (Standard)

• CAS Number: 951-78-0
• UNSPSC Description: 2'-Deoxyuridine (Standard) is the analytical standard of 2'-Deoxyuridine. This product is intended for research and analytical applications. 2’-deoxyuridine is a brain-penetrant pyrimidines nucleotide that is associated with nervous system diseases. 2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. 2'-Deoxyuridine is a precursor in the synthesis of Edoxudine (HY-B1011) and also an analogue of 5-ethynyl-2'-deoxyuridine, EdU (HY-118411). 2’-deoxyuridine reduces microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury, which is promising for research of Alzheimer’s disease (AD)[1][2][3]. In Vitro:The interaction between the 2-deoxyuridine and the column increases the duration of retention of 2-deoxyuridine[2]. Gradient elution with sodium acetate buffer-ACN eluent on two ZIC-HILIC homemade columns separates 2-deoxyuridine in under 9 min[2]. In Vivo:2'-Deoxyuridine (34.42 ng/mL, gavage, 15 min) passes the blood-brain barrier (BBB) to enter the hippocampus of mice brain[3]. 2'-Deoxyuridine (20 mg/kg, gavage, daily for 4 weeks) improves cognition and memory loss and attenuates the damage to the hippocampus in Aβ25-35-induced mice model[3].
• Target Antigen: Endogenous Metabolite; Thymidylate Synthase
• Type: Reference Standards
• Related Pathways: Apoptosis;Metabolic Enzyme/Protease
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/2-deoxyuridine-standard.html
• Smiles: O=C(N1)N([C@H]2C[C@H](O)[C@@H](CO)O2)C=CC1=O
• Molecular Weight: 228.20
• References & Citations: [1]Reidy JA, et al. Deoxyuridine increases folate-sensitive fragile site expression in human lymphocytes. Am J Med Genet. 1987 Jan;26(1):1-5.|[2]Ashraf Saad Rasheed, et al. Development of ZIC-HILIC methods using ultraviolet detection for determining 2-deoxyuridine in human serum[J]. Systematic Reviews in Pharmacy. 2020 March; 11(2):388-394.|[3]Liu M, et al. Thymidine and 2'-deoxyuridine reduce microglial activation and improve oxidative stress damage by modulating glycolytic metabolism on the Aβ25-35-induced brain injury[J]. Arch Biochem Biophys. 2022 Oct 30;729:109377.
• Shipping Conditions: Room temperature