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Tripchlorolide

CAT: 0804-HY-N10408Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N10408Size:1 Each
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Description
Tripchlorolide is a neuroprotective agent that can be found in Tripterygium wilfordii. Tripchlorolide prevents tumor growth by inducing apoptosis and autophagy. Tripchlorolide improves cognitive deficits in Alzheimer's disease[1][2][3].
CAS Number
132368-08-2
UNSPSC
12352005
Target
Apoptosis; Autophagy
Type
Natural Products
Related Pathways
Apoptosis; Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/tripchlorolide.html
Solubility
10 mM in DMSO
Smiles
C[C@@]([C@@]1([H])C2)(CCC3=C1COC3=O)[C@]4([C@@]([C@H]5Cl)([H])O4)[C@]6([C@@H]([C@@](O)5C(C)C)O)[C@@]2([H])O6
Molecular Formula
C20H25ClO6
Molecular Weight
396.86
References & Citations
[1]Li FQ, et, al. Neurotrophic and neuroprotective effects of tripchlorolide, an extract of Chinese herb Tripterygium wilfordii Hook F, on dopaminergic neurons. Exp Neurol. 2003 Jan;179 (1) :28-37.|[2]Chen L, et, al. Tripchlorolide induces cell death in lung cancer cells by autophagy. Int J Oncol. 2012 Apr;40 (4) :1066-70.|[3]Zeng Y, et, al. Tripchlorolide improves cognitive deficits by reducing amyloid β and upregulating synapse-related proteins in a transgenic model of Alzheimer's Disease. J Neurochem. 2015 Apr;133 (1) :38-52.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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