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Phosphorylethanolamine

CAT: 0804-HY-N5034-01Size: 5 gDry Ice: NoHazardous: No
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CAT#:0804-HY-N5034-01Size:5 g
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Description
Phosphorylethanolamine (Monoaminoethyl phosphate) is a membrane phospholipid and an important precursor of Phosphatidylcholine. It is found in most animal tissues and various human extracranial tumors, playing a critical role in membrane integrity, cell division, mitochondrial respiratory function, and more. Studies have shown that changes in the abundance of Phosphorylethanolamine are associated with Alzheimer's disease and Parkinson's disease. Lowering the ratio of Phosphorylethanolamine to Phosphatidylcholine in the liver can improve insulin signaling. Phosphorylethanolamine holds promise for research in the fields of cancer, neurodegenerative disorders, and metabolic diseases[1][2][3][4][5].
CAS Number
1071-23-4
Product Name Alternative
Monoaminoethyl phosphate; NSC 254167; O-Phosphoethanolamine
UNSPSC
12352211
Hazard Statement
H314
Target
Endogenous Metabolite
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Phosphorylethanolamine.html
Purity
99.90
Solubility
H2O : 125 mg/mL (ultrasonic)
Smiles
NCCOP(O)(O)=O
Molecular Formula
C2H8NO4P
Molecular Weight
141.06
Precautions
H314
References & Citations
[1]Kinoshita Y, et al. Phosphorylethanolamine content of human brain tumors. Neurol Med Chir (Tokyo) . 1994 Dec;34 (12) :803-6.|[2]Hui SCN, et al. In vivo spectral editing of phosphorylethanolamine. Magn Reson Med. 2022 Jan;87 (1) :50-56.|[3]Calzada E, et al. Phosphatidylethanolamine Metabolism in Health and Disease. Int Rev Cell Mol Biol. 2016;321:29-88. doi: 10.1016/bs.ircmb.2015.10.001. |[4]van der Veen JN, et al. A role for phosphatidylcholine and phosphatidylethanolamine in hepatic insulin signaling. FASEB J. 2019 Apr;33 (4) :5045-5057.|[5]Nesic I, et al. Alterations in phosphatidylethanolamine levels affect the generation of Aβ. Aging Cell. 2012 Feb;11 (1) :63-72.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; Microbial Metabolite

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