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STOCK2S-26016

CAT: 0804-HY-112143-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-112143-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
STOCK2S-26016 is a WNK signalling inhibitors. STOCK2S-26016 inhibits WNK4 and WNK1 with IC50s of 16 μM and 34.4 μM, respectively. STOCK2S-26016 has potential for antihypertensive research[1].
CAS Number
332922-63-1
UNSPSC
12352005
Target
Ser/Thr Protease
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/stock2s-26016.html
Purity
98.7
Solubility
DMSO : ≥ 50 mg/mL
Smiles
NC1=C(C=CC(NCC2=CC=CO2)=C3)C3=NC4=CC=C(OCC)C=C41
Molecular Formula
C20H19N3O2
Molecular Weight
333.38
References & Citations
[1]Takayasu M, et, al. Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy. Biochem J. 2013 Nov 1; 455 (3) : 339-45.|[2]Conghui W, et, al. Low dose L-NAME induces salt sensitivity associated with sustained increased blood volume and sodium-chloride cotransporter activity in rodents. Kidney Int. 2020 Jun 24; S0085-2538 (20) 30703-1.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Stock2S 26016

7-ethoxy-N(3)-(2-furanylmethyl)-3,9-acridinediamine is a member of the class of aminoacridines that is acridin-9-amine substituted by [(furan-2-yl)methyl]amino and ethoxy groups at positions 3 and 7, respectively. It is a lysine deficient protein kinase (WNK) signaling inhibitor (IC50 = 16 M). It has a role as a WNK signaling inhibitor. It is a member of furans, an aromatic amine, an aromatic ether and a member of aminoacridines.

CAS Number332922-63-1
PubChem CID3135086
IUPAC Name7-ethoxy-3-N-(furan-2-ylmethyl)acridine-3,9-diamine
Molecular FormulaC20H19N3O2
Molecular Weight333.4
XLogP3.8
Topological Polar Surface Area73.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count25
Formal Charge0
Complexity435
SMILES
CCOC1=CC2=C(C3=C(C=C(C=C3)NCC4=CC=CO4)N=C2C=C1)N
InChI
InChI=1S/C20H19N3O2/c1-2-24-14-6-8-18-17(11-14)20(21)16-7-5-13(10-19(16)23-18)22-12-15-4-3-9-25-15/h3-11,22H,2,12H2,1H3,(H2,21,23)
InChIKey
PGNWQNJXXLPZEL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Stock2S 26016
CAS: 332922-63-1
CID: 3135086
Formula: C20H19N3O2
MW: 333.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight333.4
XLogP33.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass333.147726857
Monoisotopic Mass333.147726857
Topological Polar Surface Area73.3 Ų
Heavy Atom Count25
Formal Charge0
Complexity435
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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