Histamine (dihydrochloride)
CAT:
804-HY-B0722-03
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Histamine (dihydrochloride)
- CAS Number: 56-92-8
- UNSPSC Description: Histamine dihydrochloride is a reactive oxygen species (ROS) inhibitor. Histamine dihydrochloride can suppress ROS production and work together with IL-2 to activate T cells and NK cells, leading to immune activation in the tumor microenvironment, which consequently kills acute myeloid leukemia (AML) cells. Histamine dihydrochloride can cause a reduction in vaginal tetrazo reduction, increased epithelial growth, and heightened keratinization in mouse models of ovariectomy. Histamine dihydrochloride can be used in the research of acute myeloid leukemia, malignant melanoma, and renal cell carcinoma[1][2].
- Target Antigen: Endogenous Metabolite; Reactive Oxygen Species
- Type: Natural Products
- Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
- Applications: Cancer-programmed cell death
- Field of Research: Metabolic Disease; Cancer
- Assay Protocol: https://www.medchemexpress.com/histamine-dihydrochloride.html
- Purity: 99.51
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: NCCC1=CN=CN1.Cl.Cl
- Molecular Weight: 184.07
- References & Citations: [1]MARTIN L. The effects of histamine on the vaginal epithelium of the mouse. J Endocrinol. 1962 Jan;23:329-40. |[2]Yang LP, et al. Spotlight on histamine dihydrochloride in acute myeloid leukaemia. Drugs Aging. 2011 Apr 1;28(4):325-9. Mbio. 2022 Aug 24;e0200422.|Adv Sci (Weinh). 2023 Jan 15;e2203869.|Biol Pharm Bull. 2023;46(6):864-868.|bioRxiv. 2024 June 12.|Br J Pharmacol. 2021 Jan 27.|Cancer Cell. 2022 Sep 1;S1535-6108(22)00378-6.|Front Pharmacol. 2019 Nov 15;10:1380.|J Cell Commun Signal. 2022 Oct 25.|Microbiol Spectr. 2023 Jan 31;e0469822.
- Shipping Conditions: Room Temperature
- Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
- Clinical Information: Launched