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Avrainvillamide

CAT: 0804-HY-N10264Size: 250 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-N10264Size:250 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Avrainvillamide ((+) -Avrainvillamide) is a naturally occurring alkaloid with antiproliferative effects, binds to the nuclear chaperone nucleophosmin, a proposed oncogenic protein that is overexpressed in many different human tumors. Avrainvillamide affects cell biology both by directly binding NPM1 and Crm1 as well as by inhibiting the association of these proteins with certain native cellular partners. Avrainvillamide, an antibiotic, inhibits growth of multi-agent resistant Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, with MICs of 12.5, 12.5 and 25 μg/ml, respectively[1][2][3].
CAS Number
269741-97-1
Product Name Alternative
(+) -Avrainvillamide; CJ-17,665
UNSPSC
12352005
Target
Antibiotic
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/avrainvillamide.html
Purity
95.00
Solubility
DMSO : 2.23 mg/mL (ultrasonic; warming)
Smiles
O=C1[C@]23[C@@](C(C)(C4=[N+]([O-])C5=C6C(OC(C)(C=C6)C)=CC=C5C4=C3)C)([H])CC7(C(N2)=O)N1CCC7
Molecular Formula
C26H27N3O4
Molecular Weight
445.51
References & Citations
[1]Wulff JE, et al. The natural product avrainvillamide binds to the oncoprotein nucleophosmin. J Am Chem Soc. 2007;129 (46) :14444-14451. |[2]Mukherjee H, et al. Interactions of the natural product (+) -avrainvillamide with nucleophosmin and exportin-1 Mediate the cellular localization of nucleophosmin and its AML-associated mutants. ACS Chem Biol. 2015;10 (3) :855-863. |[3]Sugie Y, et al. A new antibiotic CJ-17,665 from Aspergillus ochraceus. J Antibiot (Tokyo) . 2001;54 (11) :911-916.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Alternative Products

CatalogName
A222-1MGAvrainvillamide

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