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Letaxaban

CAT: 0804-HY-10594-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10594-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Letaxaban (TAK-442) is an orally active and selective direct FXa inhibitor. Letaxaban is a drug with dual anticoagulant and anti-inflammatory activity that works by directly inhibiting FXa and by intervening in the PAR1 signaling pathway. Letaxaban can be used in the study of thrombotic diseases, cardiovascular diseases and inflammation-related diseases[1].
CAS Number
870262-90-1
Product Name Alternative
TAK-442
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Factor Xa
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/letaxaban.html
Smiles
ClC1=CC2=C(C=C1)C=C(C=C2)S(C[C@@H](O)C(N3CCC(N4C(NCCC4)=O)CC3)=O)(=O)=O
Molecular Formula
C22H26ClN3O5S
Molecular Weight
479.98
Precautions
P261-P280-P302+P352
References & Citations
[1]Shinozawa E, et al. TAK-442, a direct factor Xa inhibitor, inhibits monocyte chemoattractant protein 1 production in endothelial cells via involvement of protease-activated receptor 1[J]. Frontiers in Pharmacology, 2018, 9: 1431.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched

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