Recombinant Human Thioredoxin (TXN) (Active)

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Dry Ice Shipment: No

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CAT:

399-CSB-AP005541HU-03

Size:

50 µg

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Recombinant Human Thioredoxin (TXN) (Active)

Gene Name: TXN
UniProt: P10599
Expression Region: 1-105aa
Organism: Homo sapiens
Target Sequence: MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV
Tag: N-terminal 6xHis-tagged
Source: E.coli
Field of Research: Signal Transduction
Assay Type: Active Protein & In Stock Protein
Relevance: Thioredoxin (TXN) is a member of the Thioredoxin family. Thioredoxin eXIsts as a disulfide-linked homodimer and contains one Thioredoxin domain. Thioredoxin is up-regulated by ionizing radiation. Thioredoxin participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Thioredoxin also plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide.
Endotoxin: Less than 1.0 EU/µg as determined by LAL method.
Purity: Greater than 95% as determined by SDS-PAGE.
Activity: Yes
Bioactivity: Measured by its ability to catalyze the reduction of insulin.The reaction leads to precipitation, which can be measured by absorbance at 650 nm. The specific activity is 0.2-1 Abs/min/mg as measured under the described conditions.
Length: Full Length
Form: Lyophilized powder
Buffer: Lyophilized from a 0.2 μm filtered 20 mM PB, 150 mM NaCl, pH 7.2
Reconstitution: We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity.; FUNCTION
Molecular Weight: 13.9 kDa
Storage Conditions: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.

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Cat	Name
CSB-EP025365HU-03	Recombinant Human Thioredoxin (TXN)
CSB-EP025365HU-02	Recombinant Human Thioredoxin (TXN)
CSB-EP025365HU-01	Recombinant Human Thioredoxin (TXN)
CSB-AP005541HU-01	Recombinant Human Thioredoxin (TXN) (Active)
CSB-EP857458HU-03	Recombinant Human Thioredoxin, mitochondrial (TXN2)
CSB-AP005541HU-02	Recombinant Human Thioredoxin (TXN) (Active)
CSB-EP857458HU-01	Recombinant Human Thioredoxin, mitochondrial (TXN2)
CSB-EP857458HU-02	Recombinant Human Thioredoxin, mitochondrial (TXN2)
CSB-AP005541HU-03	Recombinant Human Thioredoxin (TXN) (Active)
CSB-RP028144h-02	Human Thioredoxin (TXN)