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SEN12333

CAT: 0804-HY-107678-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107678-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SEN 12333 (WAY-317538) is a potent, selective and orally active α7 nAChR agonist. SEN12333 displays high affinity for the rat α7 nAChRs expressed in GH4C1 cells (K>i=260 nM) and acts as full agonist in functional Ca2+ flux studies (EC50=1.6 μM) . SEN 12333 is used for AD and schizophrenia research[1].
CAS Number
874450-44-9
Product Name Alternative
WAY-317538
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
NAChR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sen12333.html
Purity
98.45
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(CCCCN1CCOCC1)NC2=CC=C(C3=CN=CC=C3)C=C2
Molecular Formula
C20H25N3O2
Molecular Weight
339.43
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Corinne Beinat, et al. The Recent Development of α7 Nicotinic Acetylcholine Receptor (nAChR) Ligands as Therapeutic Candidates for the Treatment of Central Nervous System (CNS) Diseases.Curr Pharm Des. 2016;22 (14) :2134-51.|[2]Renza Roncarati, et al. Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders. J Pharmacol Exp Ther. 2009 May;329 (2) :459-68.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
GTR19173888-01SEN12333

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