Cromolyn

CAT: 0804-HY-B1619-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B1619-01Size:5 mg
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Description
Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC50 of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects[1][2][3][4][5].
CAS Number
[16110-51-3]
Product Name Alternative
Cromoglycate; Cromoglicic acid; FPL-670 (free acid)
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Amyloid-β; GSK-3; NF-κB
Type
Reference compound
Related Pathways
Neuronal Signaling; NF-κB; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cromolyn.html
Purity
99.91
Solubility
DMSO : 175 mg/mL (ultrasonic)
Smiles
OC(COC1=C2C(C=C(C(O)=O)OC2=CC=C1)=O)COC3=C4C(C=C(C(O)=O)OC4=CC=C3)=O
Molecular Formula
C23H16O11
Molecular Weight
468.37
Precautions
H315, H319, H335
References & Citations
[1]Oka T, et al. Evidence questioning cromolyn's effectiveness and selectivity as a 'mast cell stabilizer' in mice. Lab Invest. 2012 Oct;92 (10) :1472-82.|[2]Arumugam T, et al. Effect of cromolyn on S100P interactions with RAGE and pancreatic cancer growth and invasion in mouse models. J Natl Cancer Inst. 2006 Dec 20;98 (24) :1806-18.|[3]Granucci EJ, et al. Cromolyn sodium delays disease onset and is neuroprotective in the SOD1G93A Mouse Model of amyotrophic lateral sclerosis. Sci Rep. 2019 Nov 27;9 (1) :17728.|[4]Zhang C, et al. Cromolyn Reduces Levels of the Alzheimer's Disease-Associated Amyloid β-Protein by Promoting Microglial Phagocytosis. Sci Rep. 2018 Jan 18;8 (1) :1144.|[5]Motawi TM, et al. Naproxen and cromolyn as new glycogen synthase kinase 3β inhibitors for amelioration of diabetes and obesity: an investigation by docking simulation and subsequent in vitro/in vivo biochemical evaluation. J Biochem Mol Toxicol. 2013 Sep;27 (9) :425-36.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Int Immunopharmacol. 2025 May 19:159:114880.|Int J Mol Sci. 2025 Feb 14;26 (4) :1619.|J Invest Dermatol. 2025 Nov 4:S0022-202X (25) 03517-1.|J Med Chem. 2021 Oct 14;64 (19) :14344-14357.|Nat Commun. 2025 Jan 8;16 (1) :509.|Pharmacol Res. 2017 Nov;125 (Pt B) :150-160.|Res Sq. 2025 Apr 08.

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