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DS44960156

CAT: 0804-HY-131943-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-131943-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DS44960156 is a selective Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) inhibitor, with IC50 values of 1.6 μM and >30 μM for MTHFD2 and MTHFD1, respectively[1].
CAS Number
2361327-08-2
UNSPSC
12352005
Target
Methylenetetrahydrofolate Dehydrogenase (MTHFD)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ds44960156.html
Concentration
10mM
Purity
99.36
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)C1=CC=C(C(N2CCC(C3=CC=CC=C3O4)=C(C4=O)C2)=O)C=C1
Molecular Formula
C20H15NO5
Molecular Weight
349.34
References & Citations
[1]Junya Kawai, et al. Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold. ACS Med Chem Lett. 2019 May 24;10 (6) :893-898.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
BA7977-5.1DS44960156

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