Paeoniflorin

• Description:

  Paeoniflorin is a heat shock protein-inducing compound and commonly exists in the plants of Paeoniaceae family, with various biological activities, including anticancer activity, anti-inflammatory activity, enhancing cognition and attenuating learning impairment, anti-oxidative stress, antiplatelet aggregation, expansion of blood vessels, and reducing blood viscosity[1][2][3].

• Product Name Alternative:

  Peoniflorin

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  HSP

• Type:

  Natural Products

• Related Pathways:

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Cancer; Infection; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/paeoniflorin.html

• Purity:

  98.94

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL

• Smiles:

  O[C@H]1[C@H] (O) [C@@H] (O) [C@] ([H]) (O[C@]2 ([C@@]3 (C) O[C@]4 ([H]) O[C@@]5 (C3) O) C[C@]5 ([H]) [C@]24COC (C6=CC=CC=C6) =O) O[C@@H]1CO

• Molecular Formula:

  C23H28O11

• Molecular Weight:

  480.46

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Yan-Xi Zhou, et al. A review on the pharmacokinetics of paeoniflorin and its anti-inflammatory and immunomodulatory effects. Biomed Pharmacother. 2020 Oct;130:110505.|[2]Yongjing Xiang, et al. Paeoniflorin: a monoterpene glycoside from plants of Paeoniaceae family with diverse anticancer activities. J Pharm Pharmacol. 2020 Apr;72 (4) :483-495.|[3]Dai Yan, et al. Paeoniflorin, a novel heat shock protein-inducing compound. Cell Stress Chaperones. 2004 Winter;9 (4) :378-89. Int J Oncol. 2013 Nov;43 (5) :1643-51.|[4]Pei-Pei Li, et al. BAFF/BAFF-R involved in antibodies production of rats with collagen-induced arthritis via PI3K-Akt-mTOR signaling and the regulation of paeoniflorin. J Ethnopharmacol. 2012 May 7;141 (1) :290-300.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  Phase 3

• CAS Number:

  23180-57-6