Human TRAIL Protein

CAT: 0749-PRP1028-01Size: 10 µgDry Ice: NoHazardous: No
CAT#:0749-PRP1028-01Size:10 µg
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Background
The protein encoded by Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3.
Description
Human TRAIL protein, expressed in E. coli
Product Name Alternative
Tumor Necrosis Factor Ligand Superfamily Member 10; Apo-2 Ligand; Apo-2L; TNF-Related Apoptosis-Inducing Ligand; Protein TRAIL; CD253; TNFSF10; APO2L; TRAIL
Gene ID
8743
Accession Number
P50591
Tag
TRAIL
Type
Cytokines and proteins
Applications
No tag
Purity
> 92 % as determined by SDS-PAGE
Activity
Measured by its ability to induce cytotoxicity in the presence of the metabolic inhibitor actinomycin D.The ED50 for this effect is 26.27 ng/mL.
Molecular Weight
19.5 kDa
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Features & Benefits
Endotoxin: < 1.0 EU per µg of the protein as determined by the LAL method.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Lyophilized Human TRAIL proteinshould be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA) . Please prevent freeze-thaw cycles.
Protein Length
The recombinant human TRAIL consists of 168 amino acids and has a predicted molecular mass of 19.5 KDa.
Formulation
Lyophilized from sterile 20 mM Tris, 150 mM NaCl, pH 8.0.
Applications Notes
Human
Other Product Names
Tumor Necrosis Factor Ligand Superfamily Member 10; Apo-2 Ligand; Apo-2L; TNF-Related Apoptosis-Inducing Ligand; Protein TRAIL; CD253; TNFSF10; APO2L; TRAIL
Recommended Usage
Always centrifuge tubes before opening. It is recommended to reconstitute the lyophilized Human TRAIL protein using the buffer we provided not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
Preparation
E. coli
Accession Number URL
https://www.uniprot.org/uniprot/P50591
AA Sequence
Amino acid sequence derived from human TRAIL isoform (P50591-1) (Val114-Gly281) was expressed.

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