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Irinotecan-d10

CAT: 0804-HY-16562S-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16562S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Irinotecan-d10 is a deuterium labeled Irinotecan ((+) -Irinotecan) . Irinotecan ((+) -Irinotecan) is a topoisomerase I inhibitor, preventing religation of the DNA strand by binding to topoisomerase I-DNA complex[1].
CAS Number
718613-28-6
Product Name Alternative
(+) -Irinotecan-d10; CPT-11-d10; VAL-413-d10 (free base)
UNSPSC
12352005
Target
Autophagy; Topoisomerase
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.02
Solubility
10 mM in DMSO
Smiles
CCC1=C2C(C(N3C2)=CC([C@](O)(C(OC4)=O)CC)=C4C3=O)=NC5=CC=C(OC(N6CCC(N7C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C7([2H])[2H])CC6)=O)C=C51
Molecular Formula
C33H28D10N4O6
Molecular Weight
596.74
References & Citations
[1]Morales C, et al. Antitumoral effect of irinotecan (CPT-11) on an experimental model of malignant neuroectodermal tumor. J Neurooncol. 2002 Feb;56 (3) :219-26.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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