Artemisone

CAT: 0804-HY-19502-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-19502-01Size:5 mg

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Description

Artemisone (Artemifone) is a potent and semi-synthetic antimalarial, inhibits P. falciparum strains, with a mean IC50 of 0.83 nM[1]. Artemisone is also a potent inhibitor of human CMV[2].

CAS Number

255730-18-8

Product Name Alternative

Artemifone; BAY 44-9585

UNSPSC

12352005

Target

CMV; Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/Artemisone.html

Purity

98.0

Solubility

DMSO : 130 mg/mL (ultrasonic)

Smiles

C[C@H]1[C@H](N2CCS(CC2)(=O)=O)O[C@@]3([H])[C@]45[C@@]([C@H](C)CC[C@]51[H])([H])CC[C@@](O3)(C)OO4

Molecular Formula

C19H31NO6S

Molecular Weight

401.52

References & Citations

[1]Vivas L, et al. Antimalarial efficacy and drug interactions of the novel semi-synthetic endoperoxide artemisone in vitro and in vivo. J Antimicrob Chemother. 2007 Apr;59 (4) :658-65.|[2]Ruiyuan Cao, et al. Anti-SARS-CoV-2 Potential of Artemisinins In Vitro. ACS Infect. Dis. 2020 Jul.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Isoform

Plasmodium

Chemical Information

Artemisone

Artemisone is under investigation in clinical trial NCT00936767 (Artemisone for the Treatment of Uncomplicated Falciparum Malaria in Western Cambodia).

CAS Number	255730-18-8
PubChem CID	11531457
IUPAC Name	4-[(1R,4S,5R,8S,9R,10R,12R,13R)-1,5,9-trimethyl-11,14,15,16-tetraoxatetracyclo[10.3.1.04,13.08,13]hexadecan-10-yl]-1,4-thiazinane 1,1-dioxide
Molecular Formula	C19H31NO6S
Molecular Weight	401.5
XLogP	2.4
Topological Polar Surface Area	82.7
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	1
Heavy Atom Count	27
Formal Charge	0
Complexity	695

SMILES

C[C@@H]1CC[C@H]2[C@H]([C@@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)N5CCS(=O)(=O)CC5)C

InChI

InChI=1S/C19H31NO6S/c1-12-4-5-15-13(2)16(20-8-10-27(21,22)11-9-20)23-17-19(15)14(12)6-7-18(3,24-17)25-26-19/h12-17H,4-11H2,1-3H3/t12-,13-,14+,15+,16-,17-,18-,19-/m1/s1

InChIKey

FDMUNKXWYMSZIR-NQWKWHCYSA-N

Chemical Structure

2D Structure

CAS: 255730-18-8

CID: 11531457

Formula: C19H31NO6S

MW: 401.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	401.5
XLogP3	2.4
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	1
Exact Mass	401.18720888
Monoisotopic Mass	401.18720888
Topological Polar Surface Area	82.7 Å²
Heavy Atom Count	27
Formal Charge	0
Complexity	695
Isotope Atom Count	0
Defined Atom Stereocenter Count	8
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
M24149-01	Artemisone
A20756-10	Artemisone 10mg
A20756-50	Artemisone 50mg
A20756-100	Artemisone 100mg
A20756-25	Artemisone 25mg
A20756-5	Artemisone 5mg
A20756-1	Artemisone 1mg
A20756-10mM-D	Artemisone 10mM * 1mL in DMSO

Artemisone

Chemical Information

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