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A-81282

CAT: 0804-HY-101823ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101823ASize:1 Each
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Description
A-81282 (Abbott 81282) is an antagonist of angiotensin II's AT1 receptor, with a pA2 value of 9.64 at the AT1 receptor in rabbit aorta. A-81282 also demonstrates significant inhibitory action on the binding of [125i]_Sar1_lle8_Angiotensin_ll to rat liver membranes, with a pKI value of 8.505. A-81282 has antihypertensive activity and can effectively lower blood pressure in renal artery-ligated rats[1].
CAS Number
141872-46-0
Product Name Alternative
Abbott 81282
UNSPSC
12352005
Target
Angiotensin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/a-81282.html
Smiles
O=C(C1=CN=CN=C1N(CCCC)CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)O
Molecular Formula
C23H23N7O2
Molecular Weight
429.47
References & Citations
[1]Hancock AA, et al. Pharmacological characterization of Abbott-81282, a novel, non-peptide angiotensin-II antagonist selective for type-1 receptors. Life Sci. 1993;53 (11) :929-37.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AT1 Receptor

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