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PTEN Polyclonal Antibody

CAT: 0749-ABP0181Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP0181Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PTEN (phosphatase and tensin homolog) was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded by PTEN is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. The use of a non-canonical (CUG) upstream initiation site produces a longer isoform that initiates translation with a leucine, and is thought to be preferentially associated with the mitochondrial inner membrane. This longer isoform may help regulate energy metabolism in the mitochondria. A pseudogene of PTEN is found on chromosome 9. Alternative splicing and the use of multiple translation start codons results in multiple transcript variants encoding different isoforms.
Description
Rabbit Anti-PTEN Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
Phosphatase and tensin homolog; phosphatase and tensin homolog pseudogene 1
Gene ID
5728
Accession Number
P60484
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from PTEN at AA range: 251-300
Clonality
Polyclonal
Tag
PTEN
Applications
IF, WB, IHC, ELISA
Field of Research
Cancer#Cell Biology #Epigenetics#Metabonomics#Signal Transduction
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
50kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
PTEN Polyclonal Antibody detects endogenous levels of PTEN.
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF 1:50-200; IHC: 100-300; WB 1:500-2000; ELISA 1:10000-20000
Other Product Names
Phosphatase and tensin homolog; phosphatase and tensin homolog pseudogene 1
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/P60484
Isotype
Rabbit IgG

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