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MEK-1/2 Polyclonal Antibody

CAT: 0749-ABP0100Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP0100Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Dual specificity mitogen-activated protein kinase kinase 2 encoded by MAP2K2 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. Dual specificity mitogen-activated protein kinase kinase 2 is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.
Description
Rabbit Anti-MEK-1/2 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
MAP2K1; MEK1; PRKMK1; Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; MKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1; MAP2K2; MEK2; MKK2; PRKMK2; Dual specificity mitogen-activated protein k
Gene ID
5604/5605
Accession Number
Q02750/P36507
Reactivity
Human, Mouse, Rat, Monkey
Immunogen
Synthesized peptide derived from human MEK-1/2 around the non-phosphorylation site of S218/222
Clonality
Polyclonal
Tag
Dual specificity mitogen-activated protein kinase kinase 1
Applications
IF, WB, IHC, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
43kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
MEK-1/2 Polyclonal Antibody detects endogenous levels of MEK-1/2 protein.
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF 1:50-200; WB 1:500-2000; ELISA 1:10000-20000; IHC 1:50-300
Other Product Names
MAP2K1; MEK1; PRKMK1; Dual specificity mitogen-activated protein kinase kinase 1; MAP kinase kinase 1; MAPKK 1; MKK1; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1; MAP2K2; MEK2; MKK2; PRKMK2; Dual specificity mitogen-activated protein k
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/Q02750
Isotype
Rabbit IgG

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