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SIRT3 Rabbit Polyclonal Antibody

CAT: 0992-R1511-3Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-R1511-3Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The Silent Information Regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. In S. cerevisiae, Sir2p deacetylates histones in an NAD-dependent manner, which regulates silencing at the telomeric, rDNA and silent mating-type loci. Sir2p is the founding member of a large family, designated sirtuins, which contain a conserved catalytic domain. The human homologues, which include SIRT1-7, are divided into four main branches: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. SIRT3 is a NAD-dependent deacetylase that contains one deacetylase sirtuin-type domain. The SIRT3 protein is widely expressed and localizes to the mitochondira where it is processed by mitochondrial processing peptidase (MPP) to yield a final product. This processing is most-likely necessary for its enzymatic activity.
CAS Number
9007-83-4
Product Name Alternative
hSIRT 3 antibody hSIRT3 antibody Mitochondrial nicotinamide adenine dinucleotide dependent deacetylase antibody NAD dependent deacetylase sirtuin 3 mitochondrial antibody NAD-dependent protein deacetylase sirtuin-3, mitochondrial antibody Regulatory protein SIR2 homolog 3 antibody Silent mating type information regulation 2 S.cerevisiae homolog 3 antibody Sir 2 like 3 antibody SIR 2 like protein 3 antibody SIR 3 antibody SIR2 L3 antibody Sir2 like 3 antibody SIR2 like protein 3 antibody SIR2-like protein 3 antibody SIR2L3 antibody SIR3_HUMAN antibody SIRT 3 antibody SIRT3 antibody Sirtuin 3 antibody Sirtuin silent mating type information regulation 2 homolog 3 (S. cerevisiae) antibody Sirtuin type 3 antibody Sirtuin3 antibody
Abbreviation
hSIRT3
Swiss Prot
Q9NTG7 Human, Q8R104 Mouse,
Cellular Locus
Mitochondrion matrix
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Recombinant protein within human SIRT3 aa 51-399 / 399.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB
Positive Control
PANC-1 cell lysate, HepG2 cell lysate, Mouse liver tissue lysate, Rat liver tissue lysate.
Concentration
1 mg/mL
Dilution
WB: 1:2,000
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 44 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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