Metadherin (LYRIC) Rabbit Polyclonal Antibody
CAT:
992-R1511-10
Size:
100 µL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Metadherin (LYRIC) Rabbit Polyclonal Antibody
- Description: MTDH (metastasis adhesion protein), also known as astrocyte elevated gene-1 protein (AEG1) or lysine-rich CEACAM1 co-isolated protein (LYRIC), is a 582 amino acid single-pass membrane protein. Overexpressed in various cancers, MTDH activates the transcription factor NFκB and promotes anchorage-independent growth of immortalized astrocytes and melanocytes, which are key components of tumor growth. MTDH is also thought to enhance the seeding of tumor cells to the target organ endothelium. Localized mainly to the endoplasmic reticulum membrane, MTDH also translocates from the cytoplasm to the nucleus when induced by TNFα. MTDH also localizes to tight junctions (TJ) during the maturation of TJ complexes in epithelial cells. MTDH is found at highest levels in heart, skeletal muscle, tongue and small intestine.
- Product Name Alternative: 3D3 antibody 3D3/LYRIC antibody AEG 1 antibody AEG-1 antibody AEG1 antibody Astrocyte elevated gene 1 antibody Astrocyte elevated gene-1 protein antibody LYRIC antibody LYRIC/3D3 antibody LYRIC_HUMAN antibody Lysine rich CEACAM1 associated protein antibody Lysine rich CEACAM1 co isolated protein antibody Lysine-rich CEACAM1 co-isolated protein antibody Metadherin antibody Metastasis adhesion protein antibody MTDH antibody Protein LYRIC antibody
- Abbreviation: AEG-1,MTDH
- CAS Number: 9007-83-4
- Swiss Prot: Q86UE4 Human
- Cellular Locus: Endoplasmic reticulum membrane. Nucleus.
- Host: Rabbit
- Species Reactivity: Human, Mouse
- Immunogen: Recombinant protein within human Metadherin aa 18-253.
- Isotype: IgG
- Conjugation: Non-conjugated
- Type: Rabbit polyclonal Antibody
- Applications: WB, IF-Cell, IHC-P, FC
- Positive Control: Human skeletal muscle tissue lysate, MCF-7, Hela, N2A, SH-SY5Y, human breast tissue, mouse brain tissue.
- Concentration: 1 mg/mL
- Dilution: WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;IHC-P: 1:100-1:500;FC: 1:50-1:200
- Purity: Immunogen affinity purified.
- Form: Liquid
- Buffer: 1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
- Molecular Weight: 64 kDa
- Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
- Recombinant Antibody: No