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Nestin Rabbit Polyclonal Antibody

CAT: 0992-R1510-19Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-R1510-19Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nestin is a major intermediate filament (IF) protein of embryonic central nervous system progenitor cells. It is also a component of the dynamic IF network during muscle development, where it polymerizes with Desmin and Vimentin. Nestin co-assembles with Vimentin or a-internexin and forms heterodimer coiled-coil molecules which then further assemble into 10 nml IFs. Deletion of the IF consensus rod domain in nestin alters nestin localization in CNS precursor cells and radial glial cells in vivo. Nestin is a marker for neuroepithelial stem cells, glioma cells and tumor endothelial cells during rapid growth. During axon elongation of differen-tiation neurons, nestin localizes to the growth cones and may play a role in growth cone guidance. In the rat adrenal gland, nestin is expressed by the zona fasciculata and the zona reticularis. Nestin is also expressed by dermatomal cells and by myoblasts during the earliest stages of myogenesis.
CAS Number
9007-83-4
Product Name Alternative
ESTM 46 antibody FLJ 21841 antibody FLJ21841 antibody Intermediate filament protein antibody Nbla00170 antibody nes antibody NEST_HUMAN antibody Nestin antibody
Abbreviation
Nes
Swiss Prot
P48681 Human, Q6P5H2 Mouse
Cellular Locus
Cytoplasm
Host
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Synthetic peptid within Human Nestin aa 1,271-1,320 / 1,621.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
IHC-P
Positive Control
Human kidney, mouse brain.
Concentration
1 mg/mL
Dilution
IHC-P: 1:50-200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
207 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody
No

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