Alpha-2-macroglobulin Mouse Monoclonal Antibody [8-B10]

Alpha-2-macroglobulin Mouse Monoclonal Antibody [8-B10]

• Description: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region, a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
• Product Name Alternative: A2m antibody A2MG_HUMAN antibody Alpha 2 M antibody Alpha 2M antibody Alpha-2-M antibody Alpha-2-macroglobulin antibody C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5 antibody CPAMD5 antibody DKFZp779B086 antibody FWP007 antibody S863 7 antibody
• Abbreviation: Alpha-2-M
• CAS Number: 9007-83-4
• Swiss Prot: P01023 Human, Q61838 Mouse, P06238 Rat
• Cellular Locus: Secreted.
• Host: Mouse
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within human Alpha-2-macroglobulin aa 950-1200.
• Isotype: IgG1
• Conjugation: Non-conjugated
• Type: Mouse monoclonal Antibody
• Applications: ELISA, IF-Cell, IHC-P
• Positive Control: H22, rat uterus tissue, human liver tissue, mouse liver tissue.
• Concentration: 2 mg/mL
• Dilution: ELISA:1:1,000-1:5,000;IF-Cell:1:50;IHC-P:1:50-1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 163 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No