TGF beta 1 Recombinant Rabbit Monoclonal Antibody [PD00-17]

TGF beta 1 Recombinant Rabbit Monoclonal Antibody [PD00-17]

• Description: Transforming growth factor beta 1 or TGF-β1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis. In humans, TGF-β1 is encoded by the TGFB1 gene. TGF-β is a multifunctional set of peptides that controls proliferation, differentiation, and other functions in many cell types. TGF-β acts synergistically with transforming growth factor-alpha (TGF-α) in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGF-β activation and signaling may result in apoptosis. Many cells synthesize TGF-β and almost all of them have specific receptors for this peptide. TGF-β1, TGF-β2, and TGF-β3 all function through the same receptor signaling systems. TGF-β1 was first identified in human platelets as a protein with a molecular mass of 25 kilodaltons with a potential role in wound healing. It was later characterized as a large protein precursor (containing 390 amino acids) that was proteolytically processed to produce a mature peptide of 112 amino acids. TGF-β1 plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages. Most immune cells (or leukocytes) secrete TGF-β1.
• Product Name Alternative: Cartilage-inducing factor antibody CED antibody Differentiation inhibiting factor antibody DPD1 antibody LAP antibody Latency-associated peptide antibody Prepro transforming growth factor beta 1 antibody TGF beta 1 antibody TGF beta antibody TGF beta 1 protein antibody TGF-beta 1 protein antibody TGF-beta-1 antibody TGF-beta-5 antibody TGF-beta1 antibody TGFB antibody Tgfb-1 antibody tgfb1 antibody TGFB1_HUMAN antibody TGFbeta antibody TGFbeta1 antibody Transforming Growth Factor b1 antibody Transforming Growth Factor beta 1 antibody Transforming growth factor beta 1a antibody transforming growth factor beta-1 antibody transforming growth factor, beta 1 antibody Transforming Growth Factor-ß1 antibody
• Abbreviation: TGFB1
• CAS Number: 9000-83-3
• Swiss Prot: P01137 Human, P04202 Mouse, P17246 Rat
• Cellular Locus: Extracellular matrix, Secreted.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide (KLH-coupled) corresponding to Human TGF-Beta 1 C-terminal.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IHC-P, IF-Tissue
• Positive Control: Raji cell lysate, K-562 cell lysate, Mouse spleen tissue lysate, Rat spleen tissue lysate, A549 cell lysate, L-929 cell lysate, NIH/3T3 cell lysate, rat spleen tissue, mouse spleen tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:2,000 ;IHC-P: 1:200 ;IF-Tissue: 1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 44 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes