iFluor™ 647 Conjugated Glucose Transporter GLUT1 Recombinant Rabbit Monoclonal Antibody [SA0377]

iFluor™ 647 Conjugated Glucose Transporter GLUT1 Recombinant Rabbit Monoclonal Antibody [SA0377]

• Description: Glucose is fundamental to the metabolism of mammalian cells. Its passage across cell membranes is mediated by a family of transporters termed glucose transporters or Gluts. In adipose and muscle tissue, insulin stimulates a rapid and dramatic increase in glucose uptake, which is largely due to the redistribution of the insulin-inducible glucose transporter, Glut4. In response to insulin, Glut4 is quickly shuttled from an intracellular storage site to the plasma membrane, where it binds glucose. In contrast, the ubiquitously expressed glucose transporter Glut1 is constitutively targeted to the plasma membrane, and shows a much less dramatic translocation in response to insulin. Glut1 and Glut4 are twelve-pass transmembrane proteins (12TM) whose carboxy-termini may dictate their cellular localization. Aberrant Glut4 expression has been suggested to contribute to such maladies as obesity and diabetes. Glut4 null mice have shown that while functional Glut4 protein is not required for maintaining normal glucose levels, it is necessary for sustained growth, normal cellular glucose, fat metabolism and prolonged longevity.
• Product Name Alternative: Choreoathetosis/spasticity episodic (paroxysmal choreoathetosis/spasticity) antibody CSE antibody DYT17 antibody DYT18 antibody DYT9 antibody EIG12 antibody erythrocyte/brain antibody Erythrocyte/hepatoma glucose transporter antibody facilitated glucose transporter member 1 antibody Glucose transporter 1 antibody Glucose transporter type 1 antibody Glucose transporter type 1, erythrocyte/brain antibody GLUT antibody GLUT-1 antibody GLUT1 antibody GLUT1DS antibody GLUTB antibody GT1 antibody GTG1 antibody Gtg3 antibody GTR1_HUMAN antibody HepG2 glucose transporter antibody HTLVR antibody Human T cell leukemia virus (I and II) receptor antibody MGC141895 antibody MGC141896 antibody PED antibody RATGTG1 antibody Receptor for HTLV 1 and HTLV 2 antibody SLC2A1 antibody Solute carrier family 2 (facilitated glucose transporter), member 1 antibody Solute carrier family 2 antibody Solute carrier family 2, facilitated glucose transporter member 1 antibody
• Abbreviation: GLUT-1
• CAS Number: 9000-83-3
• Swiss Prot: P11166 Human, P17809 Mouse
• Cellular Locus: Cell membrane, Melanosome
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: Synthetic peptide within Human GLUT1 aa 443-492 / 492.
• Isotype: IgG
• Conjugation: iFluor™ 647
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: IF-Tissue
• Positive Control: Human placenta tissue.
• Concentration: 1 mg/mL
• Dilution: IF-Tissue: 1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS
• Molecular Weight: Predicted band size: 54 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes