iFluor™ 488 Conjugated CCR7 Recombinant Rabbit Monoclonal Antibody [SR36-04]

iFluor™ 488 Conjugated CCR7 Recombinant Rabbit Monoclonal Antibody [SR36-04]

• Description: C-C chemokine receptor type 7 is a protein that in humans is encoded by the CCR7 gene. Two ligands have been identified for this receptor: the chemokines (C-C motif) ligand 19 (CCL19/ELC) and (C-C motif) ligand 21 (CCL21). CCR7 has also recently been designated CD197 (cluster of differentiation 197). The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein–Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. CCR7 has been shown to stimulate dendritic cell maturation. CCR7 is also involved in homing of T cells to various secondary lymphoid organs such as lymph nodes and the spleen as well as trafficking of T cells within the spleen. Activation of dendritic cells in peripheral tissues induces CCR7 expression on the cell's surface, which recognize CCL19 and CCL21 produced in the Lymph node and increases dendritic cell expression of co-stimulation molecules (B7), and MHC class I or MHC class II.
• Product Name Alternative: BLR 2 antibody BLR2 antibody C C chemokine receptor type 7 antibody C C CKR 7 antibody C-C chemokine receptor type 7 antibody C-C CKR-7 antibody CC chemokine receptor 7 antibody CC chemokine receptor type 7 antibody CC CKR 7 antibody CC-CKR-7 antibody CCCKR7 antibody CCR 7 antibody CCR-7 antibody Ccr7 antibody CCR7_HUMAN antibody CD 197 antibody CD197 antibody CD197 antigen antibody CDw197 antibody Chemokine (C C motif) receptor 7 antibody Chemokine (C C) receptor 7 antibody Chemokine C C motif receptor 7 antibody Chemokine C C receptor 7 antibody Chemokine receptor 7 antibody Chemokine receptor 7-like protein antibody CMKBR7 antibody EBI 1 antibody EBI1 antibody Ebi1h antibody EBV Induced G Protein Coupled Receptor 1 antibody EBV-induced G-protein coupled receptor 1 antibody Epstein Barr virus induced G protein coupled receptor antibody Epstein Barr virus induced gene 1 antibody Epstein-Barr virus-induced G-protein coupled receptor 1 antibody EVI 1 antibody EVI1 antibody Lymphocyte Specific G Protein Coupled Peptide Receptor antibody MGC108519 antibody MIP 3 beta receptor antibody MIP-3 beta receptor antibody MIP3 Beta Receptor antibody
• Abbreviation: C-C CKR-7, CC-CKR-7, CCR-7, EBI1, EBV-induced G-protein coupled receptor 1
• CAS Number: 9000-83-3
• Swiss Prot: P32248 Human
• Cellular Locus: Cell membrane.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human CCR7 aa 13-62 / 378.
• Isotype: IgG
• Conjugation: iFluor™ 488
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: IF-Cell, IF-Tissue
• Positive Control: MCF-7, rat spleen tissue, human lymph nodes tissue.
• Concentration: 1 mg/mL
• Dilution: IF-Cell: 1:100;IF-Tissue: 1:50
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: Preservative: 0.02% Sodium azide Constituents: 30% Glycerol, 1% BSA, 68.98% PBS
• Molecular Weight: Predicted band size: 43 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes