CD35 Mouse Monoclonal Antibody [A4G1]

• Description:

  Complement receptor type 1 (CR1) also known as C3b/C4b receptor or CD35 (cluster of differentiation 35) is a protein that in humans is encoded by the CR1 gene. This gene is a member of the regulators of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, hyalocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized.

• Product Name Alternative:

  C3 binding protein antibody C3b/C4b receptor antibody C3BR antibody C4BR antibody CD 35 antibody CD35 antibody CD35 antigen antibody complement component (3b/4b) receptor 1 (Knops blood group) antibody complement component (3b/4b) receptor 1 including Knops blood group system antibody Complement component receptor 1 antibody Complement receptor 1 antibody Complement receptor type 1 antibody CR 1 antibody CR1 antibody CR1_HUMAN antibody KN antibody Knops blood group antigen antibody

• Abbreviation:

  Complement receptor type 1 C3b/C4b receptor CD35

• Swiss Prot:

  P17927 Human

• Cellular Locus:

  Membrane.

• Host:

  Mouse

• Species Reactivity:

  Human

• Immunogen:

  Synthetic peptide within C-terminal human CD35.

• Isotype:

  IgG1

• Conjugation:

  Non-conjugated

• Type:

  Mouse monoclonal Antibody

• Applications:

  WB, IHC-P

• Positive Control:

  TF-1 cell lysate, human kidney tissue lysate, human spleen tissue, human hodgkin lymphoma tissue, human kidney tissue, human small intestine tissue, human tonsil tissue.

• Concentration:

  2 mg/mL

• Dilution:

  WB: 1:2,000 ;IHC-P: 1:2,000

• Purity:

  Protein G affinity purified.

• Form:

  Liquid

• Buffer:

  PBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 224 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4