Iba1 Recombinant Antibody [A5C5] - Human IgG1 (Chimeric)

• Description:

  Tumor-associated calcium signal transducer 2, also known as Trop-2 and as epithelial glycoprotein-1 antigen (EGP-1), is a protein that in humans is encoded by the TACSTD2 gene. This intronless gene encodes a carcinoma-associated antigen defined by the monoclonal antibody GA733. This antigen is a member of a family including at least two type I membrane proteins. It transduces an intracellular calcium signal and acts as a cell surface receptor. Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. This antigen is the target of sacituzumab govitecan, an antibody-drug conjugate. TROP-2 is related to epithelial cell adhesion molecule (EpCAM), also called TROP-1, gp40, and KSA. Trop-1 and Trop-2 are homologous to serum IGF-II-binding proteins and appear as signal transducers. Thus, they likely represent novel cell-surface receptors and may play a role in regulating the growth of carcinoma cells. This human monoclonal chimeric antibody has been engineered from the mouse monoclonal parent antibody. By necessity, some mouse sequence is retained as part of the variable domain. When multiplexing with other mouse-derived antibodies, using cross absorbed Fc-reactive secondary antibodies are recommended.

• Product Name Alternative:

  Cell surface glycoprotein Trop 2 antibody Cell surface glycoprotein Trop-2 antibody Cell surface glycoprotein Trop2 antibody Epithelial glycoprotein 1 antibody GA733 1 antibody GA7331 antibody M1S 1 antibody M1S1 antibody Membrane component chromosome 1 surface marker 1 antibody Pancreatic carcinoma marker protein GA733 1 antibody Pancreatic carcinoma marker protein GA733-1 antibody Pancreatic carcinoma marker protein GA7331 antibody TACD 2 antibody TACD2_HUMAN antibody TACSTD 2 antibody Tacstd2 antibody Trop 2 antibody Trop2 antibody Tumor associated calcium signal transducer 2 precursor antibody Tumor-associated calcium signal transducer 2 antibody

• Abbreviation:

  Tumor-associated calcium signal transducer 2 Cell surface glycoprotein Trop-2 Membrane component chromosome 1 surface marker 1 Pancreatic carcinoma marker protein GA733-1

• Swiss Prot:

  P09758 Human

• Cellular Locus:

  Membrane.

• Species Reactivity:

  Human

• Immunogen:

  Recombinant protein within Human TROP2 aa27-274 (Extracellular) in HEK293 cell.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Recombinant Chimeric Antibody Antibody

• Applications:

  ELISA, FC

• Positive Control:

  Recombinant TROP2 protein, MDA-MB-468 cell.

• Concentration:

  1 mg/mL

• Dilution:

  ELISA: 1:5,000-1:20,000 ;FC: 1:100-1:200

• Purity:

  Protein G affinity purified.

• Form:

  Liquid

• Buffer:

  1*PBS (pH7.4).

• Molecular Weight:

  35.7 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  Yes

• CAS Number:

  9000-83-3