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Granzyme B Rabbit Polyclonal Antibody

CAT: 0992-HA500252Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500252Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse . It cleaves after Asp. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death . Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis .
CAS Number
9007-83-4
Product Name Alternative
C11 antibody Cathepsin G like 1 antibody Cathepsin G-like 1 antibody CCPI antibody CGL 1 antibody CGL1 antibody CSP B antibody CSPB antibody CTLA 1 antibody CTLA-1 antibody CTLA1 antibody CTSGL1 antibody Cytotoxic serine protease B antibody Cytotoxic T lymphocyte associated serine esterase 1 antibody Cytotoxic T lymphocyte proteinase 2 antibody Cytotoxic T-lymphocyte proteinase 2 antibody Fragmentin 2 antibody Fragmentin-2 antibody GRAB_HUMAN antibody Granzyme 2 antibody Granzyme B (granzyme 2, cytotoxic T lymphocyte associated serine esterase 1) antibody Granzyme B antibody Granzyme-2 antibody GranzymeB antibody GRB antibody Gzmb antibody Hlp antibody Human lymphocyte protein antibody Lymphocyte protease antibody Protease, serine, B antibody SECT antibody T cell serine protease 1 3E antibody T cell serine protease 1-3E antibody T-cell serine protease 1-3E antibody
Abbreviation
Granzyme B1 Publication C11 CTLA-1 Cathepsin G-like 1 CTSGL1 Cytotoxic T-lymphocyte proteinase 2 Lymphocyte protease Fragmentin-2 Granzyme-2 Human lymphocyte protein HLP SECT T-cell serine protease 1-3E
Swiss Prot
P10144 Human
Cellular Locus
Secreted.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within human Granzyme B aa 50-247.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
IHC-P, mIHC
Positive Control
human spleen tissue, human cervical cancer.
Concentration
1 mg/mL
Dilution
IHC-P: 1:400 ;mIHC: 1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 28 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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