Neurabin 1 Rabbit Polyclonal Antibody

Neurabin 1 Rabbit Polyclonal Antibody

• Description: The human PPP1R9A gene encoding neurabin I is adjacent to SGCE, PEG10, and ASB4. Neurabin I (neural tissue specific F-actin-binding protein I) was originally purified from rat brain and has been characterised as a key candidate molecule in synaptic formation and function. It has also been shown that neurabin I is highly concentrated in the synapse of developed neurons and is involved in neurite formation. The deduced 1098 amino acid sequence for rat neurabin I contains an F-actin-binding domain, a PDZ domain, and coiled-coil domains. As the name indicates, the expression of the gene and protein was shown to be brain specific in adult rat tissues. The gene symbol is based on ‘‘protein phosphatase 1, regulatory (inhibitor) subunit 9A’’ because neurabin I has been shown to bind protein phosphatase I (PP1) and inhibit its activity. The PP1/ neurabin I complex has been demonstrated to regulate actin cytoskeleton dynamics. Furthermore, molecules implicated in the control of neuronal morphology, such as p70S6K and kalirin-7 (a GTP-exchange factor), have been identified to bind the PDZ domain of neurabin I. Lastly, the C-terminus of neurabin I binds the trans-Golgi protein TGN38, suggesting it is a multi-functional molecule that regulates membrane and cytoskeletal functions.
• Product Name Alternative: FLJ20068 antibody KIAA1222 antibody NEB1_HUMAN antibody Neurabin I antibody Neurabin-1 antibody Neurabin-I antibody Neurabin1 antibody NeurabinI antibody Neural tissue specific F actin binding protein I antibody Neural tissue-specific F-actin-binding protein I antibody NRB 1 antibody NRB I antibody NRB1 antibody NRBI antibody Ppp1r9a antibody Protein phosphatase 1 regulatory (inhibitor) subunit 9A antibody Protein phosphatase 1 regulatory subunit 9A antibody
• Abbreviation: Neurabin-1 Neural tissue-specific F-actin-binding protein I Protein phosphatase 1 regulatory subunit 9A
• CAS Number: 9007-83-4
• Swiss Prot: Q9ULJ8 Human, O35867 Rat, Q7TN74 Mouse
• Cellular Locus: Cell junction, Cytoplasm, Cytoskeleton, Synapse, Synaptosome.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within human Neurabin 1 aa 1-200.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IF-Cell, IHC-P, FC
• Positive Control: Rat brain tissue, SH-SY5Y, human liver carcinoma tissue, mouse brain tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:1,000;IF-Cell: 1:50-1:100;IHC-P: 1:100-1:500;FC: 1:50-1:100
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band sizes: 123/140/145/154 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No