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Munc13-4 Rabbit Polyclonal Antibody

CAT: 0992-HA500052Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500052Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca2+-dependent secretory lysosome exocytosis in mast cells.Expressed at high levels in spleen, thymus and leukocytes. Also expressed in lung and placenta, and at very low levels in brain, heart, skeletal muscle and kidney. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.
CAS Number
9007-83-4
Product Name Alternative
FHL 3 antibody FHL3 antibody FLJ00067 antibody HLH 3 antibody HLH3 antibody HPLH 3 antibody HPLH3 antibody Jinx antibody Munc13 4 antibody Munc13-4 antibody Protein unc 13 homolog D antibody Protein unc-13 homolog D antibody UN13D_HUMAN antibody Unc 13 homolog D antibody UNC 13D antibody Unc-13 homolog D (C. elegans) antibody Unc13 homolog D (C elegans) antibody Unc13 homolog D antibody UNC13, C. elegans, homolog of, D antibody UNC13D antibody Unc13h4 antibody
Abbreviation
Protein unc-13 homolog D,Munc13-4,NC13D
Swiss Prot
Q70J99 Human, B2RUP2 Mouse, Q9R189 Rat
Cellular Locus
Cytoplasm, Endosome, Lysosome, Membrane.
Host
Rabbit
Species Reactivity
Human, Rat
Immunogen
Recombinant protein within human Munc13-4 aa 900-1090.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
Jurkat cell lysate, K562 cell lysate, rat lung tissue lysate, Hela, SHSY5Y, rat spleen tissue, human placenta tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
123 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No