Munc13-4 Rabbit Polyclonal Antibody

Munc13-4 Rabbit Polyclonal Antibody

• Description: Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca2+-dependent secretory lysosome exocytosis in mast cells.Expressed at high levels in spleen, thymus and leukocytes. Also expressed in lung and placenta, and at very low levels in brain, heart, skeletal muscle and kidney. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells.
• Product Name Alternative: FHL 3 antibody FHL3 antibody FLJ00067 antibody HLH 3 antibody HLH3 antibody HPLH 3 antibody HPLH3 antibody Jinx antibody Munc13 4 antibody Munc13-4 antibody Protein unc 13 homolog D antibody Protein unc-13 homolog D antibody UN13D_HUMAN antibody Unc 13 homolog D antibody UNC 13D antibody Unc-13 homolog D (C. elegans) antibody Unc13 homolog D (C elegans) antibody Unc13 homolog D antibody UNC13, C. elegans, homolog of, D antibody UNC13D antibody Unc13h4 antibody
• Abbreviation: Protein unc-13 homolog D,Munc13-4,NC13D
• CAS Number: 9007-83-4
• Swiss Prot: Q70J99 Human, B2RUP2 Mouse, Q9R189 Rat
• Cellular Locus: Cytoplasm, Endosome, Lysosome, Membrane.
• Host: Rabbit
• Species Reactivity: Human, Rat
• Immunogen: Recombinant protein within human Munc13-4 aa 900-1090.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Rabbit polyclonal Antibody
• Applications: WB, IF-Cell, IHC-P
• Positive Control: Jurkat cell lysate, K562 cell lysate, rat lung tissue lysate, Hela, SHSY5Y, rat spleen tissue, human placenta tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 123 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No