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hNaa50p Rabbit Polyclonal Antibody

CAT: 0992-HA500001Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-HA500001Size:100 µL
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Description
N-alpha-acetyltransferase that acetylates the N-terminus of proteins that retain their initiating methionine . Has a broad substrate specificity: able to acetylate the initiator methionine of most peptides, except for those with a proline in second position . Also displays N-epsilon-acetyltransferase activity by mediating acetylation of the side chain of specific lysines on proteins . Autoacetylates in vivo . The relevance of N-epsilon-acetyltransferase activity is however unclear: able to acetylate H4 in vitro, but this result has not been confirmed in vivo . Component of a N-alpha-acetyltransferase complex containing NAA10 and NAA15, but NAA50 does not influence the acetyltransferase activity of NAA10: this multiprotein complex probably constitutes the major contributor for N-terminal acetylation at the ribosome exit tunnel, with NAA10 acetylating all amino termini that are devoid of methionine and NAA50 acetylating other peptides . Required for sister chromatid cohesion during mitosis by promoting binding of CDCA5/sororin to cohesin: may act by counteracting the function of NAA10 .
CAS Number
9007-83-4
Product Name Alternative
MAK3 antibody FLJ13194 antibody hNAT5 antibody hSAN antibody Mak3 homolog (S. cerevisiae) antibody Mak3 homolog antibody N-acetyltransferase 13 (GCN5-related) antibody N-acetyltransferase 13 antibody N-acetyltransferase 5 antibody N-acetyltransferase san homolog antibody N-alpha-acetyltransferase 50 antibody N-alpha-acetyltransferase 50, NatE catalytic subunit antibody Naa50 antibody NAA50_HUMAN antibody NAT 5 antibody NAT13 antibody NAT5 antibody NatE catalytic subunit antibody San antibody
Abbreviation
N-alpha-acetyltransferase 50Curated hNaa50p2 N-acetyltransferase 13 N-acetyltransferase 51 hNAT51 N-acetyltransferase san homolog1 hSAN1 N-epsilon-acetyltransferase 50Curated NatE catalytic subunit
Swiss Prot
Q9GZZ1 Human, Q6PGB6 Mouse
Cellular Locus
Cytoplasm, Nucleus.
Host
Rabbit
Species Reactivity
Human, Rat, Mouse
Immunogen
Synthetic peptide within human hNaa50p aa 100-169.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
K562 cell lysates, rat lung tissue, human spleen tissue, mouse brain tissue, Daudi.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:2,000;IHC-P: 1:100-1:400;FC: 1:50-1:100
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
19 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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