TrkA+B+C Recombinant Rabbit Monoclonal Antibody [JJ084-04]

TrkA+B+C Recombinant Rabbit Monoclonal Antibody [JJ084-04]

• Description: The family of Trk receptor tyrosine kinases consists of TrkA, TrkB, and TrkC. While the sequence of these family members is highly conserved, they are activated by different neurotrophins: TrkA by NGF, TrkB by BDNF or NT4, and TrkC by NT3. In the adult nervous system, the Trk receptors regulate synaptic strength and plasticity. TrkA regulates proliferation and is important for development and maturation of the nervous system. Point mutations, deletions, and chromosomal rearrangements (chimeras) cause ligand-independent receptor dimerization and activation of TrkA. TrkA is activated in many malignancies including breast, ovarian, prostate, and thyroid carcinomas. TrkB is overexpressed in tumors such as neuroblastoma, prostate adenocarcinoma and pancreatic ductal adenocarcinoma. In neuroblastomas overexpression of TrkB correlates with unfavorable disease outcome when autocrine loops signaling tumor survival are potentiated by additional overexpression of brain-derived neurotrophic factor (BDNF). An alternatively spliced truncated TrkB isoform lacking the kinase domain is overexpressed in Wilms’ tumors and this isoform may act as a dominant-negative to TrkB signaling. Altered TrkC expression and corresponding gene mutations are seen in various forms of cancer, with increased expression a positive prognostic indicator in patients with medulloblastoma.
• Product Name Alternative: BDNF/NT-3 growth factors receptor antibody gp140trk antibody GP145-TrkB antibody GP145-TrkC antibody High affinity nerve growth factor receptor antibody MTC antibody Neurotrophic tyrosine kinase receptor type 1 antibody Neurotrophic tyrosine kinase receptor type 2 antibody Neurotrophic tyrosine kinase receptor type 3 antibody NT-3 growth factor receptor antibody NTRK1 antibody NTRK2 antibody NTRK3 antibody p140-TrkA antibody TRK antibody Trk-A antibody Trk-B antibody Trk-C antibody TRK1-transforming tyrosine kinase protein antibody TRKA antibody TRKB antibody TrkB tyrosine kinase antibody TRKC antibody TrkC tyrosine kinase antibody Tropomyosin-related kinase A antibody Tropomyosin-related kinase B antibody Tyrosine kinase receptor A antibody Tyrosine kinase receptor antibody
• Abbreviation: Trk-A, NTRK1, Trk-B, NTRK2, Trk-C, NTRK3
• CAS Number: 9000-83-3
• Swiss Prot: P04629 Human, Q16288 Human, Q16620 Human, Q3UFB7 Mouse, P15209 Mouse, Q6VNS1 Mouse, P35739 Rat, Q63604 Rat, Q03351 Rat
• Cellular Locus: Membrane, Endosome membrane.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human TrkB aa 773-822 / 822.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IHC-P
• Positive Control: Rat brain tissue lysate, mouse brain tissue lysate, N2A, SH-SY-5Y, mouse liver tissue, mouse brain tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:1,000-1:5,000;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 92 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes