Tryptophan Hydroxylase 1 (TPH1) Recombinant Rabbit Monoclonal Antibody [SC53-07]

Tryptophan Hydroxylase 1 (TPH1) Recombinant Rabbit Monoclonal Antibody [SC53-07]

• Description: Phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) comprise a small family of monooxygenases that use tetrahydropterine as a cofactor during the catabolism of aromatic L-amino acids. PAH, TH and TPH all contain catalytic domains with an amino-terminal regulatory domain and a short carboxy-terminal tetramerization domain. Each of these enzymes also contains a single ferrous iron atom, which is bound to two histidines and a glutamate and is likely to be involved in the formation of the hydroxylating intermediate. TPH is the first and rate-limiting step in the biosynthesis of serotonin in the central nervous system and melatonin in the pineal gland. Alteration of TPH function may be a key factor in the pathology of several neuropsychiatric disorders associated with serotonin, including depression, aggression, alcoholism and schizophrenia. For instance, L-DOPA, which is used as a common therapy for Parkinson’s disease (PD) patients, inhibits TPH function, which subsequently, is thought to contribute to the onset of depression in PD patients.
• Product Name Alternative: Indoleacetic acid 5 hydroxylase antibody L tryptophan hydroxylase antibody MGC119994 antibody TPH 1 antibody TPH antibody TPH1 antibody TPH1_HUMAN antibody TPRH antibody TRPH antibody Tryptophan 5 hydroxylase 1 antibody Tryptophan 5 monooxygenase 1 antibody Tryptophan 5 monooxygenase antibody Tryptophan 5-hydroxylase 1 antibody Tryptophan 5-monooxygenase 1 antibody Tryptophan hydroxylase 1 antibody
• Abbreviation: TPH1
• CAS Number: 9000-83-3
• Swiss Prot: P17752 Human, P17532 Mouse, P09810 Rat
• Cellular Locus: Cytosol, neuron projection.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human TPH1 aa 372-419 / 444.
• Isotype: IgG
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IF-Tissue, IHC-P, IP, FC
• Positive Control: HL-60 cell lysate, Hela cell lysate, rat brain tissue, mouse cerebellum tissue, Hela.
• Concentration: 1 mg/mL
• Dilution: WB: 1:500 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100 ;IP: Use at an assay dependent concentration.
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: 51 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Recombinant Antibody: Yes