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ACE2 Rabbit Polyclonal Antibody

CAT: 0992-ER1902-40Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1902-40Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Angiotensin-converting enzyme (ACE) is a carboxyl-terminal dipeptidyl exopeptidase that converts angiotensin I to the potent vasopressive hormone, angiotensin II. There are two isoforms of ACE, the pulmonary ACEP and the testicular ACET. ACEP is a glycoprotein expressed in vascular endothelial cells of the lung, liver, adrenal cortex, pancreas, kidney and spleen. The ACET isoform is expressed exclusively in adult testis by developing sperm cells, specifically late pachytene spermatocytes. Additionally, ACE inactivates bradykinin, a vasodepressor peptide, and is involved in blood pressure regulation and fluid/electrolyte homeostasis. ACE2 is the first known human homolog of ACE. Unlike ACE, which is expressed ubiquitously throughout the vasculature, ACE2 is expressed only in cardiac, renal and testicular cells. ACE2 is not sensitive to the ACE inhibitor drugs used to treat hypertension. ACE2 receptors have been shown to be the entry point into human cells for some coronaviruses, including the SARS virus[10]. A number of studies have identified that the entry point is the same for SARS-CoV-2, the COVID-19 virus.
CAS Number
9007-83-4
Product Name Alternative
ACE 2 antibody ACE related carboxypeptidase antibody ACE-related carboxypeptidase antibody ACE2 antibody ACE2_HUMAN antibody ACEH antibody Angiotensin converting enzyme 2 antibody Angiotensin converting enzyme homolog antibody Angiotensin converting enzyme like protein antibody Angiotensin I Converting Enzyme (peptidyl dipeptidase A) 2 antibody Angiotensin I converting enzyme 2 antibody Angiotensin-converting enzyme homolog antibody DKFZP434A014 antibody EC 3.4.17 antibody metalloprotease MPROT 15 antibody Metalloprotease MPROT15 antibody OTTHUMP00000022963 antibody
Abbreviation
ACEH ACE2
Swiss Prot
Q9BYF1 Human
Cellular Locus
Secreted, Cell membrane.
Host
Rabbit
Species Reactivity
Human
Immunogen
ACE2 transfected 293 cells.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, FC
Positive Control
Human kidney tissue lysates, human kidney tissue, Vero cell.
Concentration
1 mg/mL
Dilution
WB: 1:500-1:1,000 ;IHC-P:1:50-1:200 ;FC: 1:50
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 92 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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