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Mesothelin Rabbit Polyclonal Antibody

CAT: 0992-ER1803-76Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1803-76Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This gene encodes a preproprotein that is proteolytically processed to generate two protein products, megakaryocyte potentiating factor and mesothelin. Mesothelin is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. Mesothelin is over expressed in several human tumors, including mesothelioma, ovarian cancer, pancreatic adenocarcinoma and cholangiocarcinoma. The interaction between mesothelin and MUC16 (also known as CA125) may facilitate the implantation and peritoneal spread of tumors by cell adhesion. Dr. Mitchell Ho and colleagues at the National Cancer Institute identified the region (residues 296-359) consisting of 64 amino acids at the N-terminus of cell surface mesothelin as the functional binding domain for MUC16.
CAS Number
9007-83-4
Product Name Alternative
CAK 1 antibody CAK1 antibody CAK1 antigen antibody cleaved form antibody Megakaryocyte potentiating factor antibody Mesothelin antibody Mesothelin isoform 1 precursor antibody MPF antibody Msln antibody MSLN_HUMAN antibody Pre pro megakaryocyte potentiating factor antibody Pre-pro-megakaryocyte-potentiating factor antibody SMR antibody SMRP antibody Soluble MPF mesothelin related protein antibody
Abbreviation
MPF, MSLN, MPF
Swiss Prot
Q13421 Human
Cellular Locus
Cell membrane, Golgi apparatus, Membrane, Secreted.
Host
Rabbit
Species Reactivity
Human
Immunogen
Recombinant protein within Human Mesothelin aa 220-410.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, IHC-P
Positive Control
Human tonsil tissue, human lung cancer tissue, SiHa.
Concentration
1 mg/mL
Dilution
WB:1:500-1:2,000;IF-Cell:1:50;IHC-P:1:50-1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 69 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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