MMAF-d8 (hydrochloride)

MMAF-d8 (hydrochloride)

• UNSPSC Description: MMAF-d8 (hydrochloride)e is a deuterated form of MMAF hydrochloride, which is a microtubule disrupting agent.
• Target Antigen: ADC Cytotoxin; Microtubule/Tubulin
• Type: Isotope-Labeled Compounds
• Related Pathways: Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage;Cytoskeleton
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Solubility: DMSO : 100 mg/mL (ultrasonic)
• Smiles: O=C(O)[C@H](CC1=CC=CC=C1)NC([C@H](C)[C@@H](OC)[C@H]2N(C(C[C@@H](OC)[C@@H](N(C)C([C@@]([2H])(NC([C@@H](NC)C(C)C)=O)C([2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)[C@@H](C)CC)=O)CCC2)=O.Cl
• Molecular Weight: 776.47
• References & Citations: [1]Doronina SO, et al. Enhanced activity of monomethylauristatin F through monoclonal antibody delivery: effects of linker technology on efficacy and toxicity. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported