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RUNX2 Rabbit Polyclonal Antibody

CAT: 0992-ER1802-78Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0992-ER1802-78Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The mammalian Runt-related transcription factor (RUNX) family comprises three members, RUNX1 (also designated AML-1, PEBP2αB, CBFA2), RUNX2 (also designated AML-3, PEBP2αA, CBFA1, Osf2) and RUNX3 (also designated AML-2, PEBPαC, CBFA3). RUNX family members are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX2 is essential for skeletal mineralization in that it stimulates osteoblast differentiation of mesenchymal stem cells, promotes chondrocyte hypertrophy and contributes to endothelial cell migration and vascular invasion of developing bones. Regulating RUNX2 expression may be a useful therapeutic tool for promoting bone formation. Mutations in the C-terminus of RUNX2 are associated with cleidocranial dysplasia syndrome, an autosomal-dominant skeletal dysplasia syndrome that is characterized by widely patent calvarial sutures, clavicular hypoplasia, supernumerary teeth, and short stature.
CAS Number
9007-83-4
Product Name Alternative
Acute myeloid leukemia 3 protein antibody Alpha subunit 1 antibody AML3 antibody CBF alpha 1 antibody CBF-alpha-1 antibody CBFA1 antibody CCD antibody CCD1 antibody Cleidocranial dysplasia 1 antibody Core binding factor antibody Core binding factor runt domain alpha subunit 1 antibody Core binding factor subunit alpha 1 antibody Core-binding factor subunit alpha-1 antibody MGC120022 antibody MGC120023 antibody Oncogene AML 3 antibody Oncogene AML-3 antibody OSF 2 antibody OSF-2 antibody OSF2 antibody Osteoblast specific transcription factor 2 antibody Osteoblast-specific transcription factor 2 antibody OTTHUMP00000016533 antibody PEA2 alpha A antibody PEA2-alpha A antibody PEA2aA antibody PEBP2 alpha A antibody PEBP2-alpha A antibody PEBP2A1 antibody PEBP2A2 antibody PEBP2aA antibody PEBP2aA1 antibody Polyomavirus enhancer binding protein 2 alpha A subunit antibody Polyomavirus enhancer-binding protein 2 alpha A subunit antibody Runt domain antibody Runt related transcription factor 2 antibody Runt-related transcription factor 2 antibody RUNX2 antibody RUNX2_HUMAN antibody SL3 3 enhancer factor 1 alpha A subunit antibody SL3-3 enhancer factor 1 alpha A subunit antibody SL3/AKV core binding factor alpha A subunit antibody SL3/AKV core-binding factor alpha A subunit antibody
Abbreviation
CBF-alpha-1, OSF-2, PEA2-alpha A, PEBP2-alpha A, RUNX2, AML3, CBFA1, OSF2, PEBP2A
Swiss Prot
Q13950 Human
Cellular Locus
Nucleus.
Host
Rabbit
Species Reactivity
Human
Immunogen
Synthetic peptide of C-terminal human RUNX2.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IHC-P, IF-Cell
Positive Control
HL-60 cell lysate, A431, human tonsil tissue, human colon tissue.
Concentration
1 mg/mL
Dilution
WB: 1:500;IF-Cell: 1:50-1:200;IHC-P: 1:50-1:200
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 57 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No

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