NM23 Mouse Monoclonal Antibody [12A1]

NM23 Mouse Monoclonal Antibody [12A1]

• Description: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination. During GZMA-mediated cell death, works in concert with TREX1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.
• Product Name Alternative: AWD antibody AWD, drosophila, homolog of antibody GAAD antibody Granzyme A activated DNase antibody Granzyme A-activated DNase antibody GZMA activated DNase antibody Metastasis inhibition factor NM23 antibody NB antibody NBS antibody NDK A antibody NDKA antibody NDKA_HUMAN antibody NDP kinase A antibody NDPK-A antibody NDPKA antibody NM23 antibody NM23 long variant, included antibody nm23-H1 antibody NM23-M1 antibody NM23H1B, included antibody NME/NM23 nucleoside diphosphate kinase 1 antibody Nme1 antibody NME1-NME2 spliced read-through transcript, included antibody Non-metastatic cells 1, protein (NM23A) expressed in antibody Nonmetastatic cells 1, protein expressed in antibody Nonmetastatic protein 23 antibody Nonmetastatic protein 23, homolog 1 antibody Nucleoside diphosphate kinase A antibody Tumor metastatic process-associated protein antibody
• Abbreviation: NDK A, NDP kinase A, GAAD, NME1, NDPKA, NM23
• CAS Number: 9007-83-4
• Swiss Prot: P15531 Human, P15532 Mouse, Q05982 Rat
• Cellular Locus: Cytoplasm, Nucleus.
• Host: Mouse
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Synthetic peptide within Human NM23 aa 78-126 / 152.
• Isotype: IgG1
• Conjugation: Non-conjugated
• Type: Mouse monoclonal Antibody
• Applications: WB, IF-Cell, IHC-P, FC
• Positive Control: HeLa cell lysate, A431 cell lysate, A549 cell lysate, MCF7 cell lysate, Caco-2 cell lysate, PC-3M cell lysate, HepG2 cell lysate, NIH/3T3 cell lysate, C6 cell lysate, Rat brain tissue lysate, MCF7, human breast cancer tissue, human lymphoma tissue, mouse kidney tissue, rat kidney tissue.
• Concentration: 2 mg/mL
• Dilution: WB: 1:1,000-1:2,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:200-1:1,000 ;FC: 1:1,000
• Purity: Protein G affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 17 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No