HSPA1L Mouse Monoclonal Antibody [7D1]

HSPA1L Mouse Monoclonal Antibody [7D1]

• Description: This gene encodes a 70kDa heat shock protein. In conjunction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which also encode isoforms of the 70kDa heat shock protein. Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. Positive regulator of PRKN translocation to damaged mitochondria.
• Product Name Alternative: Heat shock 70 kDa protein 1 Hom antibody Heat shock 70 kDa protein 1 like antibody Heat shock 70 kDa protein 1-Hom antibody Heat shock 70 kDa protein 1-like antibody Heat shock 70 kDa protein 1L antibody Heat shock 70kD protein like 1 antibody HS71L_HUMAN antibody HSP70 1L antibody HSP70 HOM antibody HSP70-Hom antibody HSPA1L antibody hum70t antibody Spermatid specific heat shock protein 70 antibody
• Abbreviation: Heat shock 70 kDa protein 1L, HSP70-Hom, HSPA1L
• CAS Number: 9007-83-4
• Swiss Prot: P34931 Human, P16627 Mouse, P55063 Rat
• Cellular Locus: Cytosol. Secreted.
• Host: Mouse
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein with Human HSPA1L aa 335-639 / 641.
• Isotype: IgG1
• Conjugation: Non-conjugated
• Type: Mouse monoclonal Antibody
• Applications: WB, IHC-P
• Positive Control: 293 cell lysate, mouse testis tissue lysate, rat testis tissue lysate, rat testis tissue, mouse testis tissue.
• Concentration: 2 mg/mL
• Dilution: WB: 1:10,000-1:50,000 ;IHC-P: 1:50-1:100
• Purity: Immunogen affinity purified.
• Form: Liquid
• Buffer: 1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 70 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: No