ALDH4A1 Mouse Monoclonal Antibody [7E2]

• Description:

  Aldehyde dehydrogenases (ALDHs) mediate NADP+-dependent oxidation of aldehydes into acids during detoxification of alcohol-derived acetaldehyde, lipid peroxidation and metabolism of corticosteroids, biogenic amines and neurotransmitters. ALDH4A1 (aldehyde dehydrogenase 4 family member A1), also known as P5CD (Delta-1-pyrroline-5-carboxylate dehydrogenase), P5CDh, P5CDhL, P5CDhS or ALDH4, is a major enzyme involved in the proline degradation pathway. Localizing to the mitochondrial matrix, ALDH4A1 catalyzes the conversion of Delta-1-pyrroline-5-carboxylate (P5C) to glutamate. A mutation in the gene encoding ALDH4A1 results in HPII (hyperprolinemia type II), a disease characterized by an excess of P5C and proline that is associated with mental retardation and seizures.

• Product Name Alternative:

  AL4A1_HUMAN antibody aldehyde dehydrogenase 4 antibody aldehyde dehydrogenase 4 family, member A1 antibody Aldehyde dehydrogenase family 4 member A1 antibody Aldehyde dehydrogenase, family 4, subfamily A, member 1 antibody ALDH4 antibody aldh4a1 antibody Delta 1 pyrroline 5 carboxylate dehydrogenase, mitochondrial antibody Delta-1-pyrroline-5-carboxylate dehydrogenase antibody L-glutamate gamma-semialdehyde dehydrogenase antibody mitochondrial antibody mitochondrial delta-1-pyrroline 5-carboxylate dehydrogenase antibody P5C dehydrogenase antibody P5CD antibody P5CDh antibody P5CDhL antibody P5CDhS antibody Pyrroline-5-carboxylate dehydrogenase antibody RP11 128M10.1 antibody

• Abbreviation:

  P5C dehydrogenase, ALDH4A1, ALDH4, P5CDH

• Swiss Prot:

  P30038 Human, Q8CHT0 Mouse, P0C2X9 Rat

• Cellular Locus:

  Mitochondrion matrix.

• Host:

  Mouse

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic peptide within Human ALDH4A1 aa 514-563 / 563.

• Isotype:

  IgG1

• Conjugation:

  Non-conjugated

• Type:

  Mouse monoclonal Antibody

• Applications:

  WB, IHC-P, IF-Cell, IF-Tissue

• Positive Control:

  HepG2 cell lysate, SK-Br-3 cell lysate, human kidney tissue lysate, human liver tissue lysate, mouse liver tissue lysate, rat liver tissue lysate, HepG2, human kidney tissue, human liver tissue, mouse liver tissue, rat liver tissue.

• Concentration:

  2 mg/mL

• Dilution:

  WB: 1:1,000-1:5,000 ;IHC-P: 1:1,000 ;IF-Cell: 1:100 ;IF-Tissue: 1:100

• Purity:

  Protein G affinity purified.

• Form:

  Liquid

• Buffer:

  1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 62 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4