PCSK9 Mouse Monoclonal Antibody [2F1]

• Description:

  Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC-1, is a 692 amino acid protein that belongs to the peptidase S8 family and contains one peptidase S8 domain. Important in the regulation of plasma cholesterol homeostasis, PCSK9 binds to low-density lipid receptor family members LDLR, very low-density lipid receptor (VLDLR) and apolipoprotein receptor 2 (ApoER2) and promotes their degradation in intracellular acidic compartments. PCSK9 also plays a role in neuronal differentiation and apoptosis. PCSK9 is expressed in Shwann cells, neuro-epithelioma, colon carcinoma, and hepatic and pancreatic cell lines. PCSK9 levels in the brain are highest in the cerebellum during perinatal development, with ischemia causing increased levels in the adult brain. Defects in the gene encoding this protein causes the autosomal dominant disorder familial hypercholesterolemia 3 (HCHOLA3).

• Product Name Alternative:

  Convertase subtilisin/kexin type 9 preproprotein antibody FH3 antibody HCHOLA3 antibody Hypercholesterolemia autosomal dominant 3 antibody LDLCQ1 antibody NARC 1 antibody NARC-1 antibody NARC1 antibody Neural apoptosis regulated convertase 1 antibody Neural apoptosis-regulated convertase 1 antibody PC 9 antibody PC9 antibody PCSK 9 antibody PCSK9 antibody PCSK9_HUMAN antibody Proprotein convertase 9 antibody Proprotein convertase PC9 antibody Proprotein convertase subtilisin/kexin type 9 antibody PSEC0052 antibody Subtilisin/kexin like protease PC9 antibody Subtilisin/kexin-like protease PC9 antibody

• Abbreviation:

  NARC-1, PC9, PCSK9, NARC1, PSEC0052

• Swiss Prot:

  Q8NBP7 Human, Q80W65 Mouse

• Cellular Locus:

  Secreted, endoplasmic reticulum,lysosome, cytoplasm.

• Host:

  Mouse

• Species Reactivity:

  Human, Mouse

• Immunogen:

  Recombinant protein with Human PCSK9 1-201 / 692.

• Isotype:

  IgG2b

• Conjugation:

  Non-conjugated

• Type:

  Mouse monoclonal Antibody

• Applications:

  WB, IHC-P, IF-Cell, FC

• Positive Control:

  PANC-1, H22, SW1990, HepG2, human liver tissue, human colon cancer tissue, human kidney tissue, mouse kidney tissue.

• Concentration:

  2 mg/mL

• Dilution:

  WB: 1:500-1:1,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:200

• Purity:

  Protein A affinity purified.

• Form:

  Liquid

• Buffer:

  1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 74 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4