(1R,2R)-2-PCCA (hydrochloride)

(1R,2R)-2-PCCA (hydrochloride)

• CAS Number: 1609563-71-4
• UNSPSC Description: (1R,2R)-2-PCCA hydrochloride is a diastereomer of 2-PCCA, and acts as a potent GPR88 receptor agonist, with an EC50 of 3 nM in cell-free assay, and 603 nM in cell assay.
• Target Antigen: GPR88
• Type: Reference compound
• Related Pathways: GPCR/G Protein
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease
• Assay Protocol: https://www.medchemexpress.com/_1R,2R_-2-PCCA_hydrochloride_.html
• Purity: 98.08
• Solubility: DMSO : 50 mg/mL (ultrasonic)
• Smiles: CCCC1=CC=C(C2=CC=C(N(C[C@@H](N)[C@@H](C)CC)C([C@H]3[C@H](C4=CC=CC=N4)C3)=O)C=C2)C=C1.[H]Cl.[H]Cl
• Molecular Weight: 528.56
• References & Citations: [1]Bi, Yingzhi, et al. Modulators of G Protein-Coupled Receptor 88. US 20110251204 A1.|[2]Jin C, et al. Effect of Substitution on the Aniline Moiety of the GPR88 Agonist 2-PCCA: Synthesis, Structure-Activity Relationships, and Molecular Modeling Studies. ACS Chem Neurosci. 2016 Oct 19;7(10):1418-1432.|[3]Jin C, et al. Synthesis, pharmacological characterization, and structure-activity relationship studies of small molecular agonists for the orphan GPR88 receptor. ACS Chem Neurosci. 2014 Jul 16;5(7):576-87.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, stored under nitrogen)
• Clinical Information: No Development Reported