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GPLGIAGQ

CAT: 0804-HY-P2213-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P2213-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT) [1][2][3].
CAS Number
109053-09-0
UNSPSC
12352209
Target
Apoptosis; MMP
Type
Peptides
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gplgiagq.html
Purity
99.74
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N)CC[C@@H](C(O)=O)NC(CNC([C@H](C)NC([C@H]([C@@H](C)CC)NC(CNC([C@H](CC(C)C)NC([C@H]1N(C(CN)=O)CCC1)=O)=O)=O)=O)=O)=O
Molecular Formula
C31H53N9O10
Molecular Weight
711.81
References & Citations
[1]Hou W, et al. MMP2-Targeting and Redox-Responsive PEGylated Chlorin e6 Nanoparticles for Cancer Near-Infrared Imaging and Photodynamic Therapy. ACS Appl Mater Interfaces. 2016 Jan 20;8 (2) :1447-57.|[2]Zhu L, et al. Matrix metalloproteinase 2-sensitive multifunctional polymeric micelles for tumor-specific co-delivery of siRNA and hydrophobic drugs. Biomaterials. 2014 Apr;35 (13) :4213-22.|[3]Liu FH, et al. Enzyme-sensitive cytotoxic peptide-dendrimer conjugates enhance cell apoptosis and deep tumor penetration. Biomater Sci. 2018 Feb 27;6 (3) :604-613.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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