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GPLGIAGQ

CAT: 0804-HY-P2213-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P2213-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT) [1][2][3].
CAS Number
109053-09-0
UNSPSC
12352209
Target
Apoptosis; MMP
Type
Peptides
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/gplgiagq.html
Purity
99.74
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N)CC[C@@H](C(O)=O)NC(CNC([C@H](C)NC([C@H]([C@@H](C)CC)NC(CNC([C@H](CC(C)C)NC([C@H]1N(C(CN)=O)CCC1)=O)=O)=O)=O)=O)=O
Molecular Formula
C31H53N9O10
Molecular Weight
711.81
References & Citations
[1]Hou W, et al. MMP2-Targeting and Redox-Responsive PEGylated Chlorin e6 Nanoparticles for Cancer Near-Infrared Imaging and Photodynamic Therapy. ACS Appl Mater Interfaces. 2016 Jan 20;8 (2) :1447-57.|[2]Zhu L, et al. Matrix metalloproteinase 2-sensitive multifunctional polymeric micelles for tumor-specific co-delivery of siRNA and hydrophobic drugs. Biomaterials. 2014 Apr;35 (13) :4213-22.|[3]Liu FH, et al. Enzyme-sensitive cytotoxic peptide-dendrimer conjugates enhance cell apoptosis and deep tumor penetration. Biomater Sci. 2018 Feb 27;6 (3) :604-613.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

Gplgiagq
CAS Number109053-09-0
PubChem CID11721776
IUPAC Name(2S)-5-amino-2-[[2-[[(2S)-2-[[(2S,3S)-2-[[2-[[(2S)-2-[[(2S)-1-(2-aminoacetyl)pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-methylpentanoyl]amino]propanoyl]amino]acetyl]amino]-5-oxopentanoic acid
Molecular FormulaC31H53N9O10
Molecular Weight711.8
XLogP-4.2
Topological Polar Surface Area301
Hydrogen Bond Donor Count9
Hydrogen Bond Acceptor Count11
Rotatable Bond Count21
Heavy Atom Count50
Formal Charge0
Complexity1260
SMILES
CC[C@H](C)[C@@H](C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)CN
InChI
InChI=1S/C31H53N9O10/c1-6-17(4)26(30(48)36-18(5)27(45)34-14-23(42)37-19(31(49)50)9-10-22(33)41)39-24(43)15-35-28(46)20(12-16(2)3)38-29(47)21-8-7-11-40(21)25(44)13-32/h16-21,26H,6-15,32H2,1-5H3,(H2,33,41)(H,34,45)(H,35,46)(H,36,48)(H,37,42)(H,38,47)(H,39,43)(H,49,50)/t17-,18-,19-,20-,21-,26-/m0/s1
InChIKey
BLNMYSBCIVAVFK-PFZXUFBWSA-N
Chemical Structure
2D Structure
2D structure of Gplgiagq
CAS: 109053-09-0
CID: 11721776
Formula: C31H53N9O10
MW: 711.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight711.8
XLogP3-4.2
Hydrogen Bond Donor Count9
Hydrogen Bond Acceptor Count11
Rotatable Bond Count21
Exact Mass711.39153892
Monoisotopic Mass711.39153892
Topological Polar Surface Area301 Ų
Heavy Atom Count50
Formal Charge0
Complexity1260
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
TP1535-01GPLGIAGQ
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M40618GPLGIAGQ TFA
TP1624-01GPLGIAGQ TFA (109053-09-0 free base)
MBS5789335GPLGIAGQ TFA(109053-09-0 free base)

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