Methylene Blue

• UNSPSC Description:

  Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor. Methylene blue is a vasopressor and is often used as a dye in several medical procedures. Methylene blue through the nitric oxide syntase/guanylate cyclase signalling pathway to reduce prepulse inhibition. Methylene blue is a REDOX cycling compound and able to cross the blood-brain barrier. Methylene blue is a Tau aggregation inhibitor. Methylene blue reduces cerebral edema, attenuated microglial activation and reduced neuroinflammation[1][2][3].

• Target Antigen:

  Guanylate Cyclase; Microtubule/Tubulin; Monoamine Oxidase; NO Synthase

• Type:

  Dye Reagents

• Related Pathways:

  Cell Cycle/DNA Damage;Cytoskeleton;GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer; Infection; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Methylene-Blue.html

• Solubility:

  H2O : 50 mg/mL (ultrasonic)

• Smiles:

  CN(C)C1=CC=C2C(SC(C(C=C/3)=N2)=CC3=[N+](C)/C)=C1.[Cl-]

• Molecular Weight:

  319.85

• References & Citations:

  [1]Klamer D, et, al. Phencyclidine-induced behaviour in mice prevented by methylene blue. Basic Clin Pharmacol Toxicol. 2004 Feb;94(2):65-72. |[2]Hochgräfe K, et, al. Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau. Acta Neuropathol Commun. 2015 May 10;3:25.|[3]Fenn AM, et, al. Methylene blue attenuates traumatic brain injury-associated neuroinflammation and acute depressive-like behavior in mice. J Neurotrauma. 2015 Jan 15;32(2):127-38.Biomaterials. 2022: 121988.|Biomed Res Int. 2021 May 15.|Cell Rep. 2024 Feb 13;43(2):113779.|Curr Res Virol Sci. 2022;3:100019.|Evid Based Complement Alternat Med. 2020 Mar 10;2020:3524641.|Exp Ther Med. 2019 Nov;18(5):4049-4057.|Hematology. 2022 Dec;27(1):43-52.|Patent. US20230226111A1.|Patent. US20240238271A1.|Patent. US20240325538A1.|Phytother Res. 2023 Feb 14.|Redox Biol. 2020 Sep;36:101601.|Research Square Print. 2023 Feb 21.|Theranostics. 2021 Oct 17;11(20):9884-9903.|World J Gastrointest Surg. 2023 Jun 27; 15(6): 1068-1079.|BMC Cancer. 2024 Dec 3;24(1):1489.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  Launched

• CAS Number:

  61-73-4