Thalidomide-NH-C14-NH2 (hydrochloride)
CAT:
804-HY-156162-01
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Thalidomide-NH-C14-NH2 (hydrochloride)
- UNSPSC Description: Thalidomide-NH-C14-NH2 hydrochloride is a Thalidomide (HY-14658)-based cereblon ligand that recruits CRBN proteins. Thalidomide-NH-C14-NH2 hydrochloride can be connected to the target protein ligand through a linker to form a PROTAC molecule. For example, THAL-SNS-032 (HY-123937).
- Target Antigen: Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
- Type: Reference compound
- Related Pathways: Apoptosis;Autophagy;PROTAC
- Applications: Cancer-programmed cell death
- Field of Research: cancer
- Assay Protocol: https://www.medchemexpress.com/thalidomide-nh-c14-nh2-hydrochloride.html
- Solubility: 10 mM in DMSO
- Smiles: O=C1NC(C(N2C(C3=C(C(NCCCCCCCCCCCCCCN)=CC=C3)C2=O)=O)CC1)=O.Cl
- Molecular Weight: 521.09
- References & Citations: [1]Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. [Content Brief]
- Shipping Conditions: Blue Ice
- Clinical Information: No Development Reported