CLinDMA

CAT: 0804-HY-112763-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No

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CAT#:0804-HY-112763-02Size:10 mM - 1 mL

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

CLinDMA, a cationic lipid, can cause inflammatory response. CLinDMA can be used for the synthesis LNP201. LNP201 is a liposome assembly for systemic delivery of siRNA[1].

CAS Number

908860-82-2

UNSPSC

12352211

Target

Liposome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/clindma.html

Purity

99.89

Solubility

DMSO : 140 mg/mL (ultrasonic)

Smiles

C[C@@]12[C@]3([H])[C@](CC=C1C[C@H](CC2)OCCCCOC(CN(C)C)COCCCCCCCC/C=C\C/C=C\CCCCC)([H])[C@@]4([H])[C@](CC3)([C@@](CC4)([H])[C@H](C)CCCC(C)C)C

Molecular Formula

C54H97NO3

Molecular Weight

808.35

References & Citations

[1]Abrams MT, et al. Evaluation of efficacy, biodistribution, and inflammation for a potent siRNA nanoparticle: effect of dexamethasone co-treatment. Mol Ther. 2010;18 (1) :171-180.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

CLinDMA

CAS Number	908860-82-2
PubChem CID	70876560
IUPAC Name	2-[4-[[(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]butoxy]-N,N-dimethyl-3-[(9Z,12Z)-octadeca-9,12-dienoxy]propan-1-amine
Molecular Formula	C54H97NO3
Molecular Weight	808.4
XLogP	16.8
Topological Polar Surface Area	30.9
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	31
Heavy Atom Count	58
Formal Charge	0
Complexity	1170

SMILES

CCCCC/C=C\C/C=C\CCCCCCCCOCC(CN(C)C)OCCCCO[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@H]([C@@H]3CC=C2C1)CC[C@@H]4[C@H](C)CCCC(C)C)C)C

InChI

InChI=1S/C54H97NO3/c1-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-38-56-43-48(42-55(7)8)58-40-26-25-39-57-47-34-36-53(5)46(41-47)30-31-49-51-33-32-50(45(4)29-27-28-44(2)3)54(51,6)37-35-52(49)53/h13-14,16-17,30,44-45,47-52H,9-12,15,18-29,31-43H2,1-8H3/b14-13-,17-16-/t45-,47+,48?,49+,50-,51+,52+,53+,54-/m1/s1

InChIKey

PGYFLJKHWJVRMC-ZXRZDOCRSA-N

Chemical Structure

2D Structure

CAS: 908860-82-2

CID: 70876560

Formula: C54H97NO3

MW: 808.4

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	808.4
XLogP3	16.8
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	31
Exact Mass	807.74684596
Monoisotopic Mass	807.74684596
Topological Polar Surface Area	30.9 Å²
Heavy Atom Count	58
Formal Charge	0
Complexity	1170
Isotope Atom Count	0
Defined Atom Stereocenter Count	8
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	2
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
BA7907-1	CLinDMA

CLinDMA

Chemical Information

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