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Actinonin

CAT: 0804-HY-113952-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-113952-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Actinonin ((-) -Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase. Actinonin is a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM. Actinonin also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin is an apoptosis inducer. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5].
CAS Number
13434-13-4
Product Name Alternative
(-) -Actinonin
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Aminopeptidase; Antibiotic; Apoptosis; Bacterial; MMP
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/actinonin.html
Purity
98.42
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N[C@H](C(N1[C@H](CO)CCC1)=O)C(C)C)[C@H](CCCCC)CC(NO)=O
Molecular Formula
C19H35N3O5
Molecular Weight
385.50
Precautions
H302, H315, H319, H335
References & Citations
[1]Lee MD, et al. Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics. J Clin Invest. 2004 Oct;114 (8) :1107-16.|[2]Chen DZ, et al. Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor. Biochemistry. 2000 Feb 15;39 (6) :1256-62.|[3]Wahl, R.C., et al. Hydroxamate inhibitors of human gelatinase B (92 kDa) . Bioorganic & Medicinal Chemistry Letters 5 (4), 349-352 (1995) .|[4]Duke SO, et al. Modes of action of microbially-produced phytotoxins. Toxins (Basel) . 2011 Aug;3 (8) :1038-64.|[5]Kruse MN, et al. Human meprin alpha and beta homo-oligomers: cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors. Biochem J. 2004 Mar 1;378 (Pt 2) :383-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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