Plasma Kallikrein LC (Cleaved-I391) rabbit pAb

Plasma Kallikrein LC (Cleaved-I391) rabbit pAb

• Description: Catalytic activity: Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin. Disease: Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM: 612423]; also called Fletcher factor deficiency. This disorder is a blood coagulation defect. function: The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. similarity: Belongs to the peptidase S1 family. similarity: Belongs to the peptidase S1 family. Plasma kallikrein subfamily. similarity: Contains 1 peptidase S1 domain. similarity: Contains 4 apple domains. subunit: The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds.
• Synonyms: Plasma kallikrein (EC 3.4.21.34;Fletcher factor;Kininogenin;Plasma prekallikrein) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain]
• Gene ID: 3818
• UniProt: P03952
• Cellular Locus: Secreted.
• Host: Rabbit
• Species Reactivity: Human, Rat, Mouse,
• Immunogen: Synthesized peptide derived from human Plasma Kallikrein LC (Cleaved-I391)
• Clonality: Polyclonal
• Validated Applications: WB, ELISA, IHC
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
• Molecular Weight: 28 70kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.